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自我注射肉毒杆菌导致罕见的全身性肉毒中毒伪装。

Self-Administered Botulinum Injection Causing Rare Masquerade of Systemic Botulism.

作者信息

Tay Kai Wen Elvina, Ong Alvin, Tay Wei Ling, Juan Sze Joo, Chua Karen

机构信息

Post-Acute and Continuing Care, Jurong Community Hospital, Singapore, SGP.

Emergency Medicine, Ng Teng Fong General Hospital, Singapore, SGP.

出版信息

Cureus. 2024 Jul 20;16(7):e64976. doi: 10.7759/cureus.64976. eCollection 2024 Jul.

DOI:10.7759/cureus.64976
PMID:39161519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11331558/
Abstract

This report describes the case of a patient who presented to the Emergency Department (ED) with a one-week history of difficulty in breathing, generalized weakness, dysphagia, and difficulty in walking. She had self-administered 100 units of onabotulinumtoxin A (BoNT-A) by injection into her face two weeks prior for cosmetic purposes. This case study highlights the rare but potential complication of systemic botulism.

摘要

本报告描述了一名患者的病例，该患者因呼吸困难、全身无力、吞咽困难和行走困难等症状，前往急诊科就诊。两周前，她出于美容目的自行在面部注射了100单位的A型肉毒毒素（BoNT-A）。本病例研究突出了罕见但潜在的全身性肉毒中毒并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c6/11331558/c7782554913f/cureus-0016-00000064976-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c6/11331558/2f54ef2dc8bc/cureus-0016-00000064976-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c6/11331558/c7782554913f/cureus-0016-00000064976-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c6/11331558/2f54ef2dc8bc/cureus-0016-00000064976-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7c6/11331558/c7782554913f/cureus-0016-00000064976-i02.jpg

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本文引用的文献

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Effectiveness of Botulinum Toxin Injection With Casting in Children With Spastic Cerebral Palsy: A Randomized Controlled Trial.肉毒杆菌毒素注射联合石膏固定治疗痉挛型脑瘫患儿的疗效：一项随机对照试验
Cureus. 2024 Jun 2;16(6):e61515. doi: 10.7759/cureus.61515. eCollection 2024 Jun.
2
Post-stroke spasticity: follow-up and functional implications of chronic long-term treatment with botulinum toxin.脑卒中后痉挛：肉毒毒素慢性长期治疗的随访结果及其对功能的影响。
Eur J Phys Rehabil Med. 2024 Aug;60(4):581-590. doi: 10.23736/S1973-9087.24.08429-6. Epub 2024 Jun 18.
3
Botulinum Toxin A and B for Palmoplantar Hyperhidrosis.
用于治疗掌跖多汗症的A型和B型肉毒杆菌毒素
Dermatol Ther (Heidelb). 2024 Mar;14(3):805-811. doi: 10.1007/s13555-024-01113-3. Epub 2024 Mar 1.
4
Botulinum toxin in the management of parkinsonian disorders.肉毒毒素在帕金森病治疗中的应用。
Toxicon. 2023 Aug 15;232:107209. doi: 10.1016/j.toxicon.2023.107209. Epub 2023 Jul 8.
5
The Lack of Systemic and Subclinical Side Effects of Botulinum Neurotoxin Type-A in Patients Affected by Post-Stroke Spasticity: A Longitudinal Cohort Study.A型肉毒毒素治疗脑卒中后痉挛患者缺乏系统性和亚临床副作用：一项纵向队列研究。
Toxins (Basel). 2022 Aug 19;14(8):564. doi: 10.3390/toxins14080564.
6
Adverse Events Associated With Botox as Reported in a Food and Drug Administration Database.食品和药物管理局数据库中报告的肉毒杆菌毒素相关不良事件。
Aesthetic Plast Surg. 2021 Jun;45(3):1201-1209. doi: 10.1007/s00266-020-02027-z. Epub 2020 Oct 30.
7
A rare case of severe systemic life-threatening botulism caused by a local botulinum toxin-A injection.1例罕见的因局部注射A型肉毒杆菌毒素导致严重的、危及生命的全身性肉毒中毒病例。
JAAD Case Rep. 2020 Jun 25;6(9):854-857. doi: 10.1016/j.jdcr.2020.06.031. eCollection 2020 Sep.
8
Rare Complication of Botox Injection: A Case Report.肉毒杆菌毒素注射的罕见并发症：一例报告
World J Plast Surg. 2019 Jan;8(1):116-119. doi: 10.29252/wjps.8.1.116.
9
Bulbar Muscle Weakness in the Setting of Therapeutic Botulinum Injections.治疗性肉毒杆菌注射所致延髓肌无力
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Safety Profile of High-Dose Botulinum Toxin Type A in Post-Stroke Spasticity Treatment.高剂量A型肉毒毒素治疗脑卒中后痉挛的安全性。
Clin Drug Investig. 2018 Nov;38(11):991-1000. doi: 10.1007/s40261-018-0701-x.