College and Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei, China.
Front Immunol. 2023 Oct 4;14:1249826. doi: 10.3389/fimmu.2023.1249826. eCollection 2023.
The symptoms of Behçet's disease (BD), a multisystemic condition with autoimmune and inflammation as hallmarks, include arthritis, recurring oral and vaginal ulcers, skin rashes and lesions, and involvement of the nervous, gastrointestinal, and vascular systems. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), may be important regulators of inflammation and autoimmune disease. These ncRNAs are essential to the physiological and pathophysiological disease course, and miRNA in particular has received significant attention for its role and function in BD and its potential use as a diagnostic biomarker in recent years. Although promising as therapeutic targets, miRNAs must be studied further to fully comprehend how miRNAs in BD act biologically.
贝切特病（BD）是一种多系统疾病，以自身免疫和炎症为特征，其症状包括关节炎、反复发作的口腔和阴道溃疡、皮疹和皮损，以及神经系统、胃肠道和血管系统受累。非编码 RNA（ncRNA），包括 microRNAs（miRNAs）、长非编码 RNA（lncRNAs）和 circular RNA（circRNAs），可能是炎症和自身免疫性疾病的重要调节因子。这些 ncRNA 对于生理和病理疾病过程至关重要，特别是 microRNA 因其在 BD 中的作用和功能以及近年来作为诊断生物标志物的潜在用途而受到广泛关注。尽管作为治疗靶点很有前景，但 microRNA 必须进一步研究，以充分了解 BD 中 microRNA 的生物学作用。
