Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Biomed Pharmacother. 2024 Oct;179:117390. doi: 10.1016/j.biopha.2024.117390. Epub 2024 Sep 8.
The gastrointestinal tract is chronically inflamed in ulcerative colitis (UC), which has a complicated etiology involving immunological, environmental, and genetic factors. The inflammatory response that is typical of UC is significantly regulated via the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Latest research has displayed that NF-κB signaling is controlled by three main types of non-coding RNAs (ncRNAs): circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). These ncRNAs can change the expression of key genes within the NF-κB pathway by acting as molecular sponges, transcriptional regulators, and epigenetic modifiers. This review synthesizes current knowledge on the functions by which ncRNAs modulate NF-κB signaling in UC, discusses their potential as biomarkers for disease prognosis and diagnosis, and explores their therapeutic potential. Understanding the intricate interactions between ncRNAs and NF-κB signaling may provide novel insights into UC pathogenesis and targeted therapeutic strategies.
胃肠道在溃疡性结肠炎（UC）中呈慢性炎症状态，其病因复杂，涉及免疫、环境和遗传因素。UC 典型的炎症反应主要通过核因子 kappa-轻链增强子的 B 细胞（NF-κB）信号通路进行调节。最新研究表明，NF-κB 信号通路受到三种主要类型的非编码 RNA（ncRNA）的控制：环状 RNA（circRNA）、长链非编码 RNA（lncRNA）和 microRNA（miRNA）。这些 ncRNA 可以通过充当分子海绵、转录调节剂和表观遗传修饰物来改变 NF-κB 通路中关键基因的表达。本综述综合了 ncRNA 调节 UC 中 NF-κB 信号的功能的最新知识，讨论了它们作为疾病预后和诊断标志物的潜力，并探讨了它们的治疗潜力。了解 ncRNA 和 NF-κB 信号之间的复杂相互作用可能为 UC 的发病机制和靶向治疗策略提供新的见解。
