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绘制耐多药结核病临床试验的演变图谱：文献计量学综述（1965 - 2023年）

Mapping the Evolution of Clinical Trials on Drug-Resistant Tuberculosis: A Bibliometric Overview (1965-2023).

作者信息

Dagli Namrata, Haque Mainul, Kumar Santosh

机构信息

Karnavati Scientific Research Center, Karnavati School of Dentistry, Karnavati University, Gandhinagar, IND.

Pharmacology and Therapeutics, National Defence University of Malaysia, Kuala Lumpur, MYS.

出版信息

Cureus. 2024 Feb 28;16(2):e55190. doi: 10.7759/cureus.55190. eCollection 2024 Feb.

DOI:10.7759/cureus.55190
PMID:38425326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10902607/
Abstract

This study provides a comprehensive overview of the current landscape in drug-resistant tuberculosis research. An extensive electronic search was conducted on PubMed and Scopus databases to identify clinical trials related to drug-resistant tuberculosis. Network analysis and visualization were performed on the data using the Biblioshiny App and VOSviewer software. This bibliometric study focuses on revealing publication trends, leading contributors, key institutions, thematic focuses, and citation patterns. The analysis of research paper publications reveals a consistent upward trajectory over the years, characterized by periodic declines and subsequent surges. Noteworthy peaks in 2013 and 2010 are observed in Scopus and PubMed, respectively, followed by marked declines, particularly notable between 2021 and 2023. PubMed and Scopus data indicate that the United States and South Africa are the leading contributors. According to the PubMed and Scopus databases, the University of Cape Town and Stellenbosch University are the institutions that contribute the most. Keyword and thematic analyses underscore the primary research focuses on drug-resistant tuberculosis (DR-TB), including drug combination therapy, microbiological analysis of sputum, therapeutic uses of antitubercular agents, drug resistance (DR), multidrug resistance (MDR), and . The trend-topic analysis reveals dynamic shifts in research focus over time, transitioning from single-drug therapy to addressing drug resistance and highlighting the emerging need for effective drug therapy in cases of multidrug-resistant tuberculosis. Notably, most research papers on drug-resistant tuberculosis are single-country publications. Citation analysis in the Scopus database indicates that the average citation per year and mean total citation per year peaked during 2005-2006. This suggests a period of heightened impact and recognition within the research community during that timeframe. The study's findings may inform strategic planning for combating drug-resistant tuberculosis, ultimately contributing to future enhanced prevention, diagnosis, and treatment strategies.

摘要

本研究全面概述了耐药结核病研究的当前状况。在PubMed和Scopus数据库上进行了广泛的电子检索，以识别与耐药结核病相关的临床试验。使用Biblioshiny App和VOSviewer软件对数据进行了网络分析和可视化。这项文献计量研究侧重于揭示出版趋势、主要贡献者、关键机构、主题重点和引文模式。对研究论文发表情况的分析显示，多年来呈持续上升趋势，其特点是周期性下降和随后的激增。在Scopus和PubMed中分别观察到2013年和2010年的显著峰值，随后出现明显下降，在2021年至2023年期间尤为明显。PubMed和Scopus数据表明，美国和南非是主要贡献者。根据PubMed和Scopus数据库，开普敦大学和斯泰伦博斯大学是贡献最大的机构。关键词和主题分析强调了耐药结核病（DR-TB）的主要研究重点，包括联合药物治疗、痰液的微生物分析、抗结核药物的治疗用途、耐药性（DR）、多重耐药性（MDR）等。趋势-主题分析揭示了研究重点随时间的动态变化，从单一药物治疗转向解决耐药性问题，并突出了在耐多药结核病病例中对有效药物治疗的新需求。值得注意的是，大多数关于耐药结核病的研究论文都是单国发表。Scopus数据库中的引文分析表明，每年的平均引文数和每年的平均总引文数在2005 - 2006年达到峰值。这表明在该时间段内，该研究领域在研究界的影响力和认可度有所提高。该研究的结果可能为抗击耐药结核病的战略规划提供参考，最终有助于未来加强预防、诊断和治疗策略。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67be/10902607/0f5d78c3ebe4/cureus-0016-00000055190-i11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/67be/10902607/a6ce222cfadc/cureus-0016-00000055190-i12.jpg
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