Keyhani Ali, Shabani Mohammad Javad, Etesam Farnaz, Rezaeimanesh Nasim, Azimi Amirreza, Moghadasi Abdorreza Naser
Student Counseling Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Razi Educational and Therapeutic Psychiatric Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Curr J Neurol. 2023 Oct 7;22(4):204-209. doi: 10.18502/cjn.v22i4.14523.
The present study examined the prevalence of obsessive-compulsive disorder (OCD) among Iranian patients with multiple sclerosis (MS) and the relationship between OCD and the patient's demographic characteristics. The present study used a cluster sampling method to randomly select 297 patients with MS from the patients referred to the MS Clinic and Research Center of Sina University Hospital, Tehran, Iran, during 2018-2019. To gather the required data, a questionnaire consisting of demographic characteristics and disease information sections was used. Moreover, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Obsessive-Compulsive Inventory-Revised (OCI-R), and Hospital Anxiety and Depression Scale (HADS) were employed in the present study. The comparison of qualitative and quantitative values between OCD-positive and negative groups was examined with chi-square test and independent samples t-test, respectively. Binary logistic regression was used as multivariate modeling to adjust the effects of potential confounders that could distort the relation of OCD with intended variables. Data were analyzed using SPSS software. The significance level was considered lower than 0.05. Of the total of 297 patients, 77.8% were women. Moreover, analysis of the data obtained from the HADS questionnaire revealed that 11.44% (n = 34) and 15.15% (n = 45) of patients had severe depression and severe anxiety, respectively. The results of Y-BOCS indicated that the prevalence of severe OCD among patients was 19.9%. The OCI-R questionnaire revealed that the prevalence of OCD was 47.8%, which was consistent with the total of moderate, severe, and extreme values of Y-BOCS (47.9%). Furthermore, the subscales of ordering-arranging with 69 patients (22.9%) and obsessing with 46 patients (15.5%) indicated the highest frequencies as compared to other subscales. Moreover, OCD had a significant relationship with depression, anxiety, and type of MS in this regard. In this study, the prevalence rate of OCD among patients with MS was higher than its rate among the general population.
本研究调查了伊朗多发性硬化症（MS）患者中强迫症（OCD）的患病率以及强迫症与患者人口统计学特征之间的关系。本研究采用整群抽样方法，于2018 - 2019年从转诊至伊朗德黑兰新浪大学医院MS诊所及研究中心的患者中随机选取297例MS患者。为收集所需数据，使用了一份包含人口统计学特征和疾病信息部分的问卷。此外，本研究还采用了耶鲁-布朗强迫症量表（Y-BOCS）、强迫症问卷修订版（OCI-R）和医院焦虑抑郁量表（HADS）。分别用卡方检验和独立样本t检验对强迫症阳性和阴性组之间的定性和定量值进行比较。二元逻辑回归用作多变量建模，以调整可能扭曲强迫症与目标变量关系的潜在混杂因素的影响。使用SPSS软件进行数据分析。显著性水平设定为低于0.05。在总共297例患者中，77.8%为女性。此外，对从HADS问卷获得的数据进行分析发现，分别有11.44%（n = 34）和15.15%（n = 45）的患者患有重度抑郁和重度焦虑。Y-BOCS的结果表明，患者中重度强迫症的患病率为19.9%。OCI-R问卷显示强迫症的患病率为47.8%，这与Y-BOCS的中度、重度和极重度值总和（47.9%）一致。此外，与其他子量表相比，排序-整理子量表中有69例患者（22.9%）、强迫观念子量表中有46例患者（15.5%）的频率最高。此外，在这方面，强迫症与抑郁、焦虑和MS类型有显著关系。在本研究中，MS患者中强迫症患病率高于一般人群中的患病率。
