Saini Saurabh, Khan Saquib Reyaz, Kumar Masuram Bharath, Singh Kunal, Pandey Priyanshu
Otolaryngology, Varun Arjun Medical College & Rohilkhand Hospital, Shahjahanpur, IND.
Clinical Pharmacology, Varun Arjun Medical College & Rohilkhand Hospital, Shahjahanpur, IND.
Cureus. 2024 Jan 29;16(1):e53202. doi: 10.7759/cureus.53202. eCollection 2024 Jan.
This study aims to evaluate the efficacy of platelet-rich fibrin (PRF) application in tympanoplasty procedures for patients with chronic otitis media (COM), assessing its influence on graft survival and healing time.
In this prospective interventional study, conducted between January 2022 and June 2023, 80 patients diagnosed with COM were enrolled and divided into two groups. Group A underwent standard tympanic membrane repair using temporal fascia grafts (TFG), while Group B received TFG with adjunctive PRF application. The patients were observed and assessed over a 20-week postoperative period.
The study showed a significant enhancement in graft survival rates in Group B (TFG+PRF), with only one residual perforation compared to seven in Group A (TFG alone) at 20 weeks (p=0.02534). Furthermore, Group B patients experienced faster healing, achieving 97.5% graft integrity at 10 and 20 weeks, in contrast to Group A's 87.5%.
The application of PRF in tympanoplasty procedures for COM notably enhances graft stability and expedites the healing process. These findings suggest that PRF can be a valuable adjunct in otolaryngological surgeries, offering potential improvements in patient outcomes and surgical efficacy.
本研究旨在评估富血小板纤维蛋白（PRF）在慢性中耳炎（COM）患者鼓室成形术中的应用效果，评估其对移植物存活及愈合时间的影响。
在这项于2022年1月至2023年6月进行的前瞻性干预研究中，80例被诊断为COM的患者被纳入并分为两组。A组采用颞肌筋膜移植物（TFG）进行标准鼓膜修复，而B组在使用TFG的同时辅助应用PRF。在术后20周对患者进行观察和评估。
研究显示，B组（TFG+PRF）的移植物存活率显著提高，在20周时仅有1例残余穿孔，而A组（仅TFG）有7例（p=0.02534）。此外，B组患者愈合更快，在10周和20周时移植物完整性达到97.5%，而A组为87.5%。
PRF在COM鼓室成形术中的应用显著提高了移植物的稳定性并加速了愈合过程。这些发现表明，PRF在耳鼻喉科手术中可能是一种有价值的辅助手段，有望改善患者预后和手术效果。
