KLEB-33的基因组序列草图：一株属于新兴ST16谱系的具有多抗性且能形成聚合生物膜的超毒株，携带多个高毒力基因。
Draft genome sequence of KLEB-33: a convergent biofilm hyperforming multiresistant strain belonging to the emerging ST16 lineage harboring multiple hypervirulence genes.
作者信息
Silva-Bea Sergio, García-Meniño Isidro, Rey Sonia, Romero Manuel, Fernández Javier, Hammerl Jens A, Mora Azucena, Otero Ana
机构信息
Departamento de Microbioloxía e Parasitoloxía, Facultade de Bioloxía, Edificio CIBUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Aquatic One Health Research Center (ARCUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
出版信息
Microbiol Resour Announc. 2024 Apr 11;13(4):e0119223. doi: 10.1128/mra.01192-23. Epub 2024 Mar 1.
Abstract
The emergence of convergent strains showing multiresistance, characteristic of nosocomial pathotypes and hypervirulent traits typical of community-acquired isolates, makes them important models for studying pathogenesis. Here, we describe the convergent, multidrug-resistant KLEB-33 strain harboring several hypervirulence genes and make its genome available to the scientific community.
摘要
出现的具有多重耐药性的趋同菌株，具有医院感染致病型的特征以及社区获得性分离株典型的高毒力特性，使其成为研究发病机制的重要模型。在此，我们描述了携带多个高毒力基因的趋同、多重耐药KLEB-33菌株，并向科学界公开其基因组。
相似文献
1
Draft genome sequence of KLEB-33: a convergent biofilm hyperforming multiresistant strain belonging to the emerging ST16 lineage harboring multiple hypervirulence genes.
Microbiol Resour Announc. 2024 Apr 11;13(4):e0119223. doi: 10.1128/mra.01192-23. Epub 2024 Mar 1.
2
Draft genome sequence of a carbapenemase-producing (NDM-1) and multidrug-resistant, hypervirulent Klebsiella pneumoniae ST11 isolate from Pakistan, with a non-hypermucoviscous phenotype associated with rmpA2 mutation.
J Glob Antimicrob Resist. 2021 Jun;25:359-362. doi: 10.1016/j.jgar.2021.04.017. Epub 2021 May 13.
3
Phenotypic and Genotypic Characterization of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae ST17-KL38 Clinical Isolate Harboring the Carbapenemase IMP-4.
Microbiol Spectr. 2022 Apr 27;10(2):e0213421. doi: 10.1128/spectrum.02134-21. Epub 2022 Feb 28.
4
Presence of hypervirulence-associated determinants in Klebsiella pneumoniae from hospitalised patients in Germany.
Int J Med Microbiol. 2024 Mar;314:151601. doi: 10.1016/j.ijmm.2024.151601. Epub 2024 Feb 8.
5
Emergence of hypermucoviscous colistin-resistant high-risk convergent ST-2096 clone from Pakistan.
Future Microbiol. 2022 Sep;17:989-1000. doi: 10.2217/fmb-2021-0292. Epub 2022 Jul 21.
6
Emergence of Extensively Drug-Resistant and Hypervirulent KL2-ST65 Klebsiella pneumoniae Harboring in Beijing, China.
Microbiol Spectr. 2022 Dec 21;10(6):e0304422. doi: 10.1128/spectrum.03044-22. Epub 2022 Nov 14.
7
Unusual Hypermucoviscous Clinical Isolate of Klebsiella pneumoniae with No Known Determinants of Hypermucoviscosity.
Microbiol Spectr. 2022 Jun 29;10(3):e0039322. doi: 10.1128/spectrum.00393-22. Epub 2022 Jun 1.
8
Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene Inserted via Insertion Sequence Elements.
Microbiol Spectr. 2022 Dec 21;10(6):e0240022. doi: 10.1128/spectrum.02400-22. Epub 2022 Oct 12.
9
Genomic Epidemiology of Carbapenem-Resistant in Qatar: Emergence and Dissemination of Hypervirulent Klebsiella pneumoniae Sequence Type 383 Strains.
Antimicrob Agents Chemother. 2023 Jul 18;67(7):e0003023. doi: 10.1128/aac.00030-23. Epub 2023 Jun 13.
10
Multiple detection of hypermucoviscous and hypervirulent strains of Klebsiella pneumoniae: An emergent health care threat.
Acta Microbiol Immunol Hung. 2022 Nov 22;69(4):297-302. doi: 10.1556/030.2022.01908. Print 2022 Dec 6.
引用本文的文献
1
Regulatory effects on virulence and phage susceptibility revealed by mutation in .
Front Cell Infect Microbiol. 2025 Mar 13;15:1562402. doi: 10.3389/fcimb.2025.1562402. eCollection 2025.
本文引用的文献
1
Comparative analysis of multidrug-resistant Klebsiella pneumoniae strains of food and human origin reveals overlapping populations.
Int J Food Microbiol. 2024 Mar 2;413:110605. doi: 10.1016/j.ijfoodmicro.2024.110605. Epub 2024 Jan 23.
2
A Comprehensive Genomic Analysis of the Emergent ST16 Lineage: Virulence, Antimicrobial Resistance and a Comparison with the Clinically Relevant ST11 Strain.
Pathogens. 2022 Nov 22;11(12):1394. doi: 10.3390/pathogens11121394.
3
Species-Specific Quality Control, Assembly and Contamination Detection in Microbial Isolate Sequences with AQUAMIS.
Genes (Basel). 2021 Apr 26;12(5):644. doi: 10.3390/genes12050644.
4
Virulence Factors in Hypervirulent .
Front Microbiol. 2021 Apr 8;12:642484. doi: 10.3389/fmicb.2021.642484. eCollection 2021.
5
A global perspective on the convergence of hypervirulence and carbapenem resistance in Klebsiella pneumoniae.
J Glob Antimicrob Resist. 2021 Jun;25:26-34. doi: 10.1016/j.jgar.2021.02.020. Epub 2021 Mar 2.
6
Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniae Pathogenesis.
Infect Immun. 2021 Mar 17;89(4). doi: 10.1128/IAI.00693-20.
7
Hypervirulent Klebsiella pneumoniae.
Clin Microbiol Rev. 2019 May 15;32(3). doi: 10.1128/CMR.00001-19. Print 2019 Jun 19.
8
Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications.
Wellcome Open Res. 2018 Sep 24;3:124. doi: 10.12688/wellcomeopenres.14826.1. eCollection 2018.
9
NCBI prokaryotic genome annotation pipeline.
Nucleic Acids Res. 2016 Aug 19;44(14):6614-24. doi: 10.1093/nar/gkw569. Epub 2016 Jun 24.
Zotero 插件