Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Center for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, India.
Methods Mol Biol. 2024;2761:337-354. doi: 10.1007/978-1-0716-3662-6_25.
The gradual loss of neurons' structure and function in the central nervous system is known as neurodegeneration. It is a defining feature of several incapacitating illnesses, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. The buildup of amyloid beta (Aβ) protein in the brain is one of the several variables linked to neurodegeneration. We shall delve into the fascinating realm of Aβ in this chapter and examine its role in the etiology of neurodegenerative illnesses. Insights into the processes through which Aβ exerts its toxicity are crucial for the creation of therapeutic approaches to treat these life-threatening diseases. Despite the presence of multiple obstacles, recent research shows promise for the development of some new anti-Aβ therapies that will help millions of people suffering from neurodegeneration. In this chapter, we discuss the role of Aβ in contributing to neurotoxicity and several anti-Aβ therapies for neuroprotection.
中枢神经系统中神经元结构和功能的逐渐丧失被称为神经退行性变。它是几种使人丧失能力的疾病的一个特征，如阿尔茨海默病、帕金森病和亨廷顿病。大脑中淀粉样β（Aβ）蛋白的堆积是与神经退行性变相关的几个变量之一。我们将在这一章深入探讨 Aβ 的迷人领域，并研究其在神经退行性疾病发病机制中的作用。了解 Aβ 发挥毒性的过程对于开发治疗这些危及生命的疾病的治疗方法至关重要。尽管存在多种障碍，但最近的研究为开发一些新的抗 Aβ疗法带来了希望，这些疗法将帮助数以百万计的神经退行性变患者。在这一章中，我们讨论了 Aβ 在导致神经毒性中的作用和几种用于神经保护的抗 Aβ 疗法。
