Department of Anesthesiology, China Medical University Hospital, Taichung, Taiwan (R.O.C.).
School of Medicine, Duke University, Durham, NC, United States of America.
PLoS One. 2024 Mar 1;19(3):e0289519. doi: 10.1371/journal.pone.0289519. eCollection 2024.
Patients diagnosed with stage III breast cancer often undergo surgery, radiation therapy, and chemotherapy as part of their treatment. The choice of anesthesia technique during surgery has been a subject of interest due to its potential association with immune changes and prognosis. In this study, we aimed to compare the mortality rates between stage III breast cancer patients undergoing surgery with propofol-based intravenous general anesthesia and those receiving inhaled anesthetics.
Using data from Taiwan's National Health Insurance Research Database and Taiwan Cancer Registry, we identified a cohort of 10,896 stage III breast cancer patients. Among them, 1,506 received propofol-based intravenous anesthetic maintenance, while 9,390 received inhaled anesthetic maintenance. To ensure comparability between the two groups, we performed propensity-score matching.
Our findings revealed a significantly lower mortality rate in patients who received inhaled anesthetics compared to those who received propofol-based intravenous anesthesia. Sensitivity analysis further confirmed the robustness of our results.
This study suggests that inhaled anesthesia technique is associated with a lower mortality rate in clinical stage III breast cancer. Further research is needed to validate and expand upon these results.
诊断为 III 期乳腺癌的患者通常接受手术、放疗和化疗作为其治疗的一部分。由于麻醉技术与免疫变化和预后之间存在潜在关联，因此手术期间选择麻醉技术一直是研究的热点。在这项研究中，我们旨在比较接受丙泊酚静脉全身麻醉和吸入麻醉维持的 III 期乳腺癌患者的死亡率。
我们使用来自台湾全民健康保险研究数据库和台湾癌症登记处的数据，确定了 10896 名 III 期乳腺癌患者的队列。其中，1506 名患者接受丙泊酚静脉麻醉维持，9390 名患者接受吸入麻醉维持。为了确保两组之间的可比性，我们进行了倾向评分匹配。
我们的研究结果表明，接受吸入麻醉的患者死亡率明显低于接受丙泊酚静脉麻醉的患者。敏感性分析进一步证实了我们结果的稳健性。
这项研究表明，吸入麻醉技术与临床 III 期乳腺癌患者的低死亡率相关。需要进一步的研究来验证和扩展这些结果。
