Vanni R, Peretti D, Scarpa R M, Usai E
Cancer Genet Cytogenet. 1985 Apr 15;16(4):289-95. doi: 10.1016/0165-4608(85)90235-3.
Cytogenetic studies on bladder carcinomas from two patients were carried out on preparations obtained by a direct method. The chromosome mode was 49 and 55, respectively. Several karyotypic changes were found in the tumors. Moreover, the analysis of Q-banded chromosomes revealed the presence in both cases of a chromosome 11p+. These rearranged chromosomes showed a very similar banding pattern. The finding of a der(11) chromosome marker in two patients is intriguing, and suggests the possibility of nonrandom chromosome changes in bladder carcinoma, as already found in other kinds of tumors. The occurrence of chromosome #11 aberrations in tumors of the urinary tract is discussed in connection with the current theories on oncogenesis.
对两名患者的膀胱癌进行了细胞遗传学研究，研究材料通过直接法获取。染色体众数分别为49和55。在肿瘤中发现了几种核型变化。此外，对Q带染色体的分析显示，两例病例均存在11号染色体短臂增加（11p+）。这些重排染色体显示出非常相似的带型模式。在两名患者中发现der(11)染色体标记很有意思，这表明膀胱癌可能存在非随机染色体变化，正如在其他类型肿瘤中已发现的那样。结合当前的肿瘤发生理论，讨论了尿路肿瘤中11号染色体畸变的发生情况。
