Atkin N B, Baker M C
Cancer Genet Cytogenet. 1985 Feb 15;15(3-4):253-68. doi: 10.1016/0165-4608(85)90169-4.
In direct preparations of ten untreated transitional cell carcinomas of the bladder, chromosomes #1 and #11 were most frequently involved in structural changes (in at least seven tumors each). Three tumors had one or two 11p- chromosomes, and, in other tumors, chromosome #11 had taken part in translocations or isochromosome formation, which, except in one tumor, resulted in a loss of short arm material. Also, there was a tendency for the presence of fewer than expected normal chromosomes #11. Chromosome #1 anomalies are common in most types of tumor; however, chromosome #11 abnormalities, particularly the loss of short arm material, are not common and may thus characterize carcinoma of the bladder, a finding that is of interest in view of the location of an oncogene, c-Ha-ras1, on 11p. Translocations probably involved chromosome #17 in four tumors. Structurally changed chromosomes #3 were seen in four tumors, including one or two 3q- chromosomes in two or possibly three tumors.
在对10例未经治疗的膀胱移行细胞癌进行的直接制片中，1号和11号染色体最常发生结构改变（每种改变至少在7个肿瘤中出现）。3个肿瘤有1条或2条11p-染色体，在其他肿瘤中，11号染色体参与了易位或等臂染色体形成，除1个肿瘤外，这均导致短臂物质缺失。此外，还存在11号正常染色体数量少于预期的趋势。1号染色体异常在大多数肿瘤类型中都很常见；然而，11号染色体异常，特别是短臂物质缺失并不常见，因此可能是膀胱癌的特征，鉴于致癌基因c-Ha-ras1位于11p上，这一发现很有意思。4个肿瘤中的易位可能涉及17号染色体。在4个肿瘤中可见结构改变的3号染色体，其中2个或可能3个肿瘤中有1条或2条3q-染色体。
