Xiao Qian, Zhang Gui, Zhong Yuan
Mental Health Centre of Xiangya Hospital, Central South University, Changsha 410008, Hunan, China.
School of Psychology, Nanjing Normal University, Nanjing 210097, China.
Psychiatry Res Neuroimaging. 2024 Jun;340:111802. doi: 10.1016/j.pscychresns.2024.111802. Epub 2024 Feb 23.
The symptoms of pediatric bipolar disorder (PBD)-I and PBD-II differ, but accurate identification at an early stage is difficult and may prevent effective treatment of this disorder. Therefore, it is urgent to elucidate a biological marker based on objective imaging indicators to help distinguish the two. Therefore, this research aims to compare the functional connectivity between PBD-I patient and PBD-II patient in different brain networks.
Our study enrolled 31 PBD-I and 23 PBD-II patients from 12 to 17 years of age. They were analyzed by resting state-functional connectivity through Independent component analysis (ICA).
We found differences between PBD-I and PBD-II in functional connectivity of the default network, frontoparietal network, salience network and limbic system. In addition, the clinical features, cognitive functions are associated with the functional connectivity of the intrinsic networks in PBD-I and PBD-II separately.
This research is the first to find differences in functional connectivity between PBD-I and PBD-II, suggesting that abnormality of the functional connectivity within large networks may be biomarkers that help differentiate PBD-I from PBD-II in the future.
儿童双相情感障碍（PBD）-I型和PBD-II型的症状有所不同，但早期准确识别较为困难，这可能会阻碍对该疾病的有效治疗。因此，迫切需要基于客观成像指标阐明一种生物标志物，以帮助区分这两种类型。因此，本研究旨在比较PBD-I型患者和PBD-II型患者在不同脑网络中的功能连接性。
我们的研究纳入了31名年龄在12至17岁之间的PBD-I型患者和23名PBD-II型患者。通过独立成分分析（ICA）对他们进行静息态功能连接性分析。
我们发现PBD-I型和PBD-II型在默认网络、额顶网络、突显网络和边缘系统的功能连接性方面存在差异。此外，临床特征、认知功能分别与PBD-I型和PBD-II型内在网络的功能连接性相关。
本研究首次发现PBD-I型和PBD-II型在功能连接性上存在差异，表明大网络内功能连接性异常可能是未来有助于区分PBD-I型和PBD-II型的生物标志物。
