Pediatric Brain Research and Intervention Center, Institute for Juvenile Research and Colbeth Clinic, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
J Psychiatry Neurosci. 2013 Jul;38(4):232-40. doi: 10.1503/jpn.120073.
The aim of the present study was to map the pathophysiology of resting state functional connectivity accompanying structural and functional abnormalities in children with bipolar disorder.
Children with bipolar disorder and demographically matched healthy controls underwent resting-state functional magnetic resonance imaging. A model-free independent component analysis was performed to identify intrinsically interconnected networks.
We included 34 children with bipolar disorder and 40 controls in our analysis. Three distinct resting state networks corresponding to affective, executive and sensorimotor functions emerged as being significantly different between the pediatric bipolar disorder (PBD) and control groups. All 3 networks showed hyperconnectivity in the PBD relative to the control group. Specifically, the connectivity of the dorsal anterior cingulate cortex (ACC) differentiated the PBD from the control group in both the affective and the executive networks. Exploratory analysis suggests that greater connectivity of the right amygdala within the affective network is associated with better executive function in children with bipolar disorder, but not in controls.
Unique clinical characteristics of the study sample allowed us to evaluate the pathophysiology of resting state connectivity at an early state of PBD, which led to the lack of generalizability in terms of comorbid disorders existing in a typical PBD population.
Abnormally engaged resting state affective, executive and sensorimotor networks observed in children with bipolar disorder may reflect a biological context in which abnormal task-based brain activity can occur. Dual engagement of the dorsal ACC in affective and executive networks supports the neuroanatomical interface of these networks, and the amygdala's engagement in moderating executive function illustrates the intricate interplay of these neural operations at rest.
本研究旨在描绘伴有结构和功能异常的双相障碍儿童静息态功能连接的病理生理学。
双相障碍儿童和人口统计学匹配的健康对照组接受静息态功能磁共振成像。采用无模型独立成分分析来识别内在连接的网络。
我们的分析纳入了 34 名双相障碍儿童和 40 名对照。三个不同的静息态网络，对应情感、执行和感觉运动功能，在儿科双相障碍（PBD）和对照组之间存在显著差异。所有 3 个网络在 PBD 中相对于对照组均表现出过度连接。具体来说，背侧前扣带皮层（ACC）的连接在情感和执行网络中均能将 PBD 与对照组区分开来。探索性分析表明，右侧杏仁核在情感网络中的连接性越强，儿童双相障碍的执行功能越好，但在对照组中并非如此。
研究样本的独特临床特征允许我们在 PBD 的早期阶段评估静息状态连接的病理生理学，这导致了存在于典型 PBD 人群中的共病障碍的可推广性不足。
在双相障碍儿童中观察到的异常参与的静息态情感、执行和感觉运动网络可能反映了异常任务相关脑活动可能发生的生物学背景。背侧 ACC 在情感和执行网络中的双重参与支持了这些网络的神经解剖界面，杏仁核在调节执行功能中的参与说明了这些神经操作在静息状态下的复杂相互作用。
