Immunometabolism of Skeletal Muscle and Exercise Research Group, Department of Physical Education, Faculty of Science and Technology, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil. Professor at Graduate Program in Science and Health, Federal University of Piaui (UFPI), Teresina-PI, Brazil and Graduate Program in Movement Science Interunits, São Paulo State University (UNESP), Presidente Prudente, SP, Brazil.
Santo Amaro University, Post-graduate Program in Health Sciences, Sao Paulo, Brazil.
Psychiatry Res. 2024 Apr;334:115805. doi: 10.1016/j.psychres.2024.115805. Epub 2024 Feb 20.
Depression and subthreshold depressive symptoms reduce quality of life and function and treatment does not work effectively in one-third of patients. Exercise can reduce depressive symptoms, but more information is required regarding strength training (ST). The objective of the present meta-analysis was to summarize and estimate the efficacy of ST in people with a diagnosis of depression or subthreshold depressive symptoms and no other severe disease. We also aimed to explore the variables that could influence the antidepressant effects. PubMed, Embase, Web of Science, PsyINFO, CINAHL, and SPORTDiscus were searched from inception to August 2022. The overall effect antidepressant of training was moderate (SMD = -0.51, 95 % CI -0.72 to -0.30, p < 0.001). The meta-regression demonstrated preliminary evidence that the variables: duration of the intervention in weeks, weekly frequency of the intervention, number of sets, and number of repetitions can influence the antidepressant effects. However, these variables had a small role in the variation of the effect.
抑郁和亚临床抑郁症状会降低生活质量和功能，三分之一的患者的治疗效果并不显著。运动可以减轻抑郁症状，但对于力量训练（ST），我们还需要更多的信息。本荟萃分析的目的是总结和评估 ST 对诊断为抑郁症或亚临床抑郁症状且无其他严重疾病的人群的疗效。我们还旨在探讨可能影响抗抑郁效果的变量。从开始到 2022 年 8 月，我们检索了 PubMed、Embase、Web of Science、PsyINFO、CINAHL 和 SPORTDiscus。训练的整体抗抑郁效果为中度（SMD = -0.51，95 % CI -0.72 至 -0.30，p < 0.001）。元回归初步表明，干预持续时间（以周计）、干预每周频率、组数和重复次数等变量可能会影响抗抑郁效果。然而，这些变量在效果的变化中作用较小。
