Veronese Nicola, Ragusa Francesco Saverio, Sabico Shaun, Dominguez Ligia Juliana, Barbagallo Mario, Duque Gustavo, Smith Lee, Al-Daghri Nasser
Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, 90127 Palermo, Italy.
Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Bone Rep. 2025 May 5;25:101848. doi: 10.1016/j.bonr.2025.101848. eCollection 2025 Jun.
Osteosarcopenia (i.e., the co-existence of osteoporosis and sarcopenia) and depression are highly prevalent among older people. However, the association between osteosarcopenia and depression in older people is largely unknown. Therefore, the present study aims to investigate this possible association in a representative sample of the older adult population in Europe and Israel.
Osteosarcopenia was defined as the concomitant presence of osteoporosis and sarcopenia; depressive symptoms in the SHARE study were self-reported using the EURO-D scale. The association between the presence of osteosarcopenia at baseline in people free from depression and incident depression during 12 years of follow-up was analyzed using a Cox's regression analysis, adjusting for several baseline covariates.
16,452 participants were included (mean age 63.7, SD 9.6; females 50.6 %). During the follow-up period, 5056 participants (31.1 % of the initial population) became depressed. People affected by osteosarcopenia became depressed in more than half of the cases compared to a quarter of controls. After adjusting for several potential baseline confounding variables, only sarcopenia (HR, hazard ratio = 1.17; 95 % CI, confidence intervals 1.04-1.32; = 0.009) and osteosarcopenia (HR = 1.27; CI 95 % 1.12-1.58; = 0.003) were significantly associated with a higher risk of depression.
Definition of sarcopenia using an anthropometric equation; definition of depression using the EURO-D scale.
The present study identified a significant association between osteosarcopenia and depression over 12 years of follow-up, mainly driven by sarcopenia. If future research confirms the present findings, it may then be prudent to target those with osteosarcopenia to aid in the prevention of onset depression.
骨少肌症（即骨质疏松症和肌肉减少症并存）和抑郁症在老年人中极为普遍。然而，老年人中骨少肌症与抑郁症之间的关联在很大程度上尚不清楚。因此，本研究旨在对欧洲和以色列老年人群的代表性样本中这一可能的关联进行调查。
骨少肌症定义为骨质疏松症和肌肉减少症同时存在；在“健康、退休和晚年生活调查”（SHARE）研究中，抑郁症状通过欧洲抑郁症量表（EURO-D）进行自我报告。使用Cox回归分析，对无抑郁症的人群在基线时骨少肌症的存在与12年随访期间新发抑郁症之间的关联进行分析，并对几个基线协变量进行调整。
纳入16452名参与者（平均年龄63.7岁，标准差9.6；女性占50.6%）。在随访期间，5056名参与者（占初始人群的31.1%）出现抑郁。与四分之一的对照组相比，受骨少肌症影响的人群中超过一半的人出现抑郁。在对几个潜在的基线混杂变量进行调整后，只有肌肉减少症（风险比，HR = 1.17；95%置信区间，CI 1.04 - 1.32；P = 0.009）和骨少肌症（HR = 1.27；95%CI 1.12 - 1.58；P = 0.003）与更高的抑郁风险显著相关。
使用人体测量方程定义肌肉减少症；使用欧洲抑郁症量表定义抑郁症。
本研究确定了在12年的随访中骨少肌症与抑郁症之间存在显著关联，主要由肌肉减少症驱动。如果未来的研究证实了本研究结果，那么针对骨少肌症患者进行干预以预防抑郁症的发生可能是明智的。
