COVID-19 重症监护病房住院一年后焦虑和抑郁症状的患病率。
Prevalence of symptoms of anxiety and depression one year after intensive care unit admission for COVID-19.
机构信息
Department of Radiology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden.
Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital/Östra, Region Västra Götaland, Gothenburg, Sweden.
出版信息
BMC Psychiatry. 2024 Mar 1;24(1):170. doi: 10.1186/s12888-024-05603-8.
BACKGROUND
To the best of our knowledge, the long term prevalence of symptoms of anxiety and depression in ICU admitted individuals after COVID-19 in Sweden during the first wave of the pandemic has not been investigated. Furthermore, no studies have exclusively investigated the risk factors for experiencing symptoms of anxiety and depression in this population.
AIM
The aim of this study was to determine the prevalence of symptoms of anxiety and depression at one year after ICU admission for COVID-19. An additional aim was to identify any early predictors that are associated with symptoms of anxiety and depression, at one year following ICU admission for COVID-19.
METHODS
This multicenter cohort study had a cross-sectional and a longitudinal design. The primary outcomes and dependent variables, symptoms of anxiety and depression, were assessed using the Hospital Anxiety and Depression Scale (HADS). The independent variables were related to demographic factors, comorbidities, and complications during COVID-19-related ICU admission. Logistic regression analyses were performed to identify any predictors of symptoms of anxiety and depression.
RESULTS
Out of 182 eligible individuals, 105 participated in the study. Symptoms of anxiety was found in 40 (38.1%) and depression in 37 (35.2%) of the participants. Using univariable logistic regression analyses, female sex was identified as a predictor of depression as defined by HADS at one year following ICU admission for COVID-19 (odds ratio 2.53, 95% confidence intervals 1.01-6.34, p-value 0.048).
CONCLUSIONS
The high prevalence of symptoms of anxiety and depression in ICU admitted individuals one year after COVID-19 is a public health issue of concern. Our findings imply that individuals who recovered after an ICU stay for COVID-19 may benefit from long-term follow-ups and continuous mental health support for more than a year following the ICU admission. For women specifically, this is true.
TRIAL REGISTRATION
The study was registered at researchweb.org on 28 May 2020 (Project number: 274477).
背景
据我们所知，在 COVID-19 大流行期间瑞典第一波疫情中，在 ICU 接受治疗的 COVID-19 患者在 ICU 出院后出现焦虑和抑郁症状的长期流行情况尚未得到调查。此外，尚无研究专门调查该人群出现焦虑和抑郁症状的危险因素。
目的
本研究旨在确定 COVID-19 患者 ICU 出院后一年时出现焦虑和抑郁症状的患病率。另一个目的是确定与 COVID-19 患者 ICU 出院后一年时出现焦虑和抑郁症状相关的任何早期预测因素。
方法
这项多中心队列研究采用了横断面和纵向设计。主要结局和因变量为焦虑和抑郁症状，使用医院焦虑和抑郁量表（HADS）进行评估。自变量与人口统计学因素、合并症和 COVID-19 相关 ICU 住院期间的并发症有关。进行逻辑回归分析以确定焦虑和抑郁症状的任何预测因素。
结果
在 182 名符合条件的患者中，有 105 名参与了研究。在参与者中，有 40 名（38.1%）出现焦虑症状，37 名（35.2%）出现抑郁症状。使用单变量逻辑回归分析，女性被确定为 COVID-19 患者 ICU 出院后一年时 HADS 定义的抑郁的预测因素（比值比 2.53，95%置信区间 1.01-6.34，p 值 0.048）。
结论
COVID-19 后一年，ICU 接受治疗的患者出现焦虑和抑郁症状的高患病率是一个值得关注的公共卫生问题。我们的研究结果表明，COVID-19 后 ICU 住院康复的患者可能需要超过一年的长期随访和持续的心理健康支持。对于女性来说，尤其如此。
试验注册
该研究于 2020 年 5 月 28 日在 researchweb.org 上注册（项目编号：274477）。
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