表观遗传转录记忆的遗传。
Inheritance of epigenetic transcriptional memory.
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
出版信息
Curr Opin Genet Dev. 2024 Apr;85:102174. doi: 10.1016/j.gde.2024.102174. Epub 2024 Mar 1.
Epigenetic memory allows organisms to stably alter their transcriptional program in response to developmental or environmental stimuli. Such transcriptional programs are mediated by heritable regulation of the function of enhancers and promoters. Memory involves read-write systems that enable self-propagation and mitotic inheritance of cis-acting epigenetic marks to induce stable changes in transcription. Also, in response to environmental cues, cells can induce epigenetic transcriptional memory to poise inducible genes for faster induction in the future. Here, we discuss modes of epigenetic inheritance and the molecular basis of epigenetic transcriptional memory.
表观遗传记忆使生物体能够在发育或环境刺激下稳定地改变其转录程序。这种转录程序是通过增强子和启动子功能的可遗传调节来介导的。记忆涉及读写系统，这些系统能够使顺式作用的表观遗传标记自我传播和有丝分裂遗传，从而诱导转录的稳定变化。此外，细胞还可以响应环境线索诱导表观遗传转录记忆，使可诱导基因在未来更快地诱导。在这里，我们讨论了表观遗传遗传的模式和表观遗传转录记忆的分子基础。
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