头发中的铁、铜和镁浓度与食管癌风险：一项巢式病例对照研究。
Iron, Copper, and Magnesium Concentration in Hair and Risk of Esophageal Cancer: A Nested Case-Control Study.
作者信息
Hashemian Maryam, Poustchi Hossein, Sharafkhah Maryam, Pourshams Akram, Mohammadi-Nasrabadi Fatemeh, Hekmatdoost Azita, Malekzadeh Reza
机构信息
Digestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Biology Department, School of Arts and Sciences, Utica University, Utica, NY, USA.
出版信息
Arch Iran Med. 2023 Dec 1;26(12):665-670. doi: 10.34172/aim.2023.98.
BACKGROUND
An association has already been hypothesized between iron, copper, and magnesium status assessed through food frequency questionnaires (FFQs) and the risk of esophageal squamous cell carcinoma (ESCC). However, self-reported dietary assessment methods are prone to measurement errors. We studied the association between iron, copper, and magnesium status and ESCC risk, using hair samples as a long exposure biomarker.
METHODS
We designed a nested case-control study within the Golestan Cohort Study, that recruited about 50000 participants in 2004-2008, and collected biospecimens at baseline. We identified 96 incident cases of ESCC with available hair samples. They were age-matched with cancer-free controls from the cohort. We used inductively coupled plasma mass spectrometry (ICP-MS) to measure iron, copper, and magnesium concentrations in hair samples. We used multiple logistic regression models to determine odds ratios and 95% confidence intervals.
RESULTS
Median concentrations of iron, copper, and magnesium were 35.4, 19.3, and 41.7 ppm in cases and 25.8, 18.3, and 50.0 ppm in controls, respectively. Iron was significantly associated with the risk of ESCC in continuous analysis (OR=1.41, 95% CI=1.03-1.92), but not in the tertiles analyses (OR=1.81, 95% CI=0.77-4.28). No associations were observed between copper and magnesium and ESCC risk, in either the tertiles models or the continuous estimate (copper: OR=2.56, 95% CI=1.00-6.54; magnesium: OR=0.75, 95% CI=0.32-1.78).
CONCLUSION
Higher iron status may be related to a higher risk of ESCC in this population.
背景
通过食物频率问卷（FFQ）评估的铁、铜和镁状态与食管鳞状细胞癌（ESCC）风险之间的关联已被提出假设。然而，自我报告的饮食评估方法容易出现测量误差。我们使用头发样本作为长期暴露生物标志物，研究了铁、铜和镁状态与ESCC风险之间的关联。
方法
我们在戈勒斯坦队列研究中设计了一项巢式病例对照研究，该研究在2004 - 2008年招募了约50000名参与者，并在基线时收集了生物标本。我们确定了96例有可用头发样本的ESCC新发病例。他们与队列中无癌对照进行年龄匹配。我们使用电感耦合等离子体质谱（ICP-MS）测量头发样本中铁、铜和镁的浓度。我们使用多元逻辑回归模型来确定比值比和95%置信区间。
结果
病例组中铁、铜和镁的中位数浓度分别为35.4、19.3和41.7 ppm，对照组分别为25.8、18.3和50.0 ppm。在连续分析中，铁与ESCC风险显著相关（OR = 1.41，95% CI = 1.03 - 1.92），但在三分位数分析中不相关（OR = 1.81，95% CI = 0.77 - 4.28）。在三分位数模型或连续估计中，均未观察到铜和镁与ESCC风险之间的关联（铜：OR = 2.56，95% CI = 1.00 - 6.54；镁：OR = 0.75，95% CI = 0.32 - 1.78）。
结论
在该人群中，较高的铁状态可能与较高的ESCC风险相关。
Zotero 插件