Uzun Hakkı, Huner Merve, Kıvrak Mehmet, Zengin Ertan, Ozsagir Yusuf Önder, Sönmez Berat, Akça Görkem
Department of Urology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey.
Department of Biochemistry, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey.
Clin Exp Reprod Med. 2024 Mar;51(1):48-56. doi: 10.5653/cerm.2023.06114. Epub 2023 Oct 24.
This study investigated the relationship of anthropometric and metabolic risk factors with seminal and sex steroidal hormone parameters in a screened population of healthy males.
The participants were healthy young men without chronic or congenital diseases. The body composition parameters that we investigated were measured weight, height, and waist circumference (WC), as well as bioelectrical impedance analysis. Semen samples were analyzed for semen volume, sperm concentration, sperm motility and morphology, seminal pH, and liquefaction time. Biochemistry analysis, including glucose and lipid metabolism parameters, was conducted on fasting blood samples. Testicular volume was calculated separately for each testis using ultrasonography.
Body mass index exhibited an inverse association with total sperm count. WC showed negative correlations with numerous seminal parameters, including sperm concentration, total sperm count, sperm morphology, and follicle-stimulating hormone levels. The basal metabolic rate was associated with seminal pH, liquefaction time, and sperm motility. WC, fat mass percentage, and triglyceride levels exhibited negative correlations with sex hormone binding globulin. The measures of glucose metabolism were associated with a greater number of seminal parameters than the measures of cholesterol metabolism. C-reactive protein levels were inversely associated with sperm concentration and total sperm count.
Anthropometric and metabolic risk factors were found to predict semen quality and alterations in sex steroidal hormone levels.
本研究在一组经过筛选的健康男性人群中，调查人体测量学和代谢风险因素与精液及性激素参数之间的关系。
参与者为无慢性或先天性疾病的健康年轻男性。我们所调查的身体成分参数包括测量体重、身高和腰围（WC），以及生物电阻抗分析。对精液样本进行精液量、精子浓度、精子活力和形态、精液pH值及液化时间的分析。对空腹血样进行生化分析，包括葡萄糖和脂质代谢参数。使用超声分别计算每个睾丸的体积。
体重指数与精子总数呈负相关。腰围与众多精液参数呈负相关，包括精子浓度、精子总数、精子形态和促卵泡激素水平。基础代谢率与精液pH值、液化时间和精子活力相关。腰围、体脂百分比和甘油三酯水平与性激素结合球蛋白呈负相关。与胆固醇代谢指标相比，葡萄糖代谢指标与更多的精液参数相关。C反应蛋白水平与精子浓度和精子总数呈负相关。
发现人体测量学和代谢风险因素可预测精液质量和性激素水平的变化。
