Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Psychophysiology. 2024 Jun;61(6):e14550. doi: 10.1111/psyp.14550. Epub 2024 Mar 3.
Motivationally significant events like oddball stimuli elicit both a characteristic event-related potential (ERPs) known as P300 and a set of autonomic responses including a phasic pupil dilation. Although co-occurring, P300 and pupil-dilation responses to oddball events have been repeatedly found to be uncorrelated, suggesting separate origins. We re-examined their relationship in the context of a three-stimulus version of the auditory oddball task, independently manipulating the frequency (rare vs. repeated) and motivational significance (relevance for the participant's task) of the stimuli. We used independent component analysis to derive a P300b component from EEG traces and linear modeling to separate a stimulus-related pupil-dilation response from a potentially confounding action-related response. These steps revealed that, once the complexity of ERP and pupil-dilation responses to oddball targets is accounted for, the amplitude of phasic pupil dilations and P300b are tightly and positively correlated (across participants: r = .69 p = .002), supporting their coordinated generation.
动机相关事件，如奇特刺激，会引发特征性事件相关电位（ERP），即 P300，以及一系列自主反应，包括瞳孔瞬间扩张。尽管同时发生，但对奇特事件的 P300 和瞳孔扩张反应一直被发现是不相关的，这表明它们有不同的起源。我们在听觉奇特任务的三刺激版本的背景下重新检查了它们的关系，独立地操纵刺激的频率（罕见与重复）和动机意义（与参与者任务的相关性）。我们使用独立成分分析从 EEG 轨迹中提取 P300b 成分，并使用线性模型从潜在的混杂动作相关反应中分离出与刺激相关的瞳孔扩张反应。这些步骤表明，一旦考虑到对奇特目标的 ERP 和瞳孔扩张反应的复杂性，相位瞳孔扩张的幅度和 P300b 之间是紧密且呈正相关的（在参与者之间：r=0.69，p=0.002），支持它们的协调产生。
