Kandasamy Geetha, Subramani Thangamani, Sam Gigi, Almanasef Mona, Almeleebia Tahani, Shorog Eman, Alshahrani Asma M, Hmlan Amjad, Al Suhaym Atheer Y, Prabahar Kousalya, Veeramani Vinoth Prabhu, Amirthalingam Palanisamy
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Department of Pharmacy Practice, Grace College of Pharmacy, Palakkad, India.
Front Cardiovasc Med. 2024 Feb 16;11:1268791. doi: 10.3389/fcvm.2024.1268791. eCollection 2024.
In postmenopausal states, women may not maintain blood pressure (BP) in the same way as men, even though most women follow their treatment plans and prescriptions more consistently than men. Biological and lifestyle factors influence the progression of hypertension in postmenopausal women (PMW). This study aimed to determine biosocial predictors associated with achieving the target BP in PMW with hypertension.
A prospective observational study was conducted in the General Medicine Department at Karuna Medical College Hospital, Kerala, India. The definition of BP goal attainment was established based on the guidelines outlined by the VIII Joint National Committee 2014 (JNC VIII). Multivariate logistic regression analysis was used to analyse biosocial predictors, such as educational status, employment status, body mass index (BMI), number of children, age at menarche, age at menopause, and number of co-morbidities, associated with BP goal achievement.
Of the patients, 56.4% achieved their BP goals on monotherapy and 59.7% achieved it on combination therapy. Level of education [odds ratio (OR) = 1.275, 95% confidence interval (CI): 0.234-7.172], employment status (OR = 0.853, 95% CI: 0.400-1.819), age at menopause (OR = 1.106, 95% CI: 0.881-1.149), number of children (OR = 1.152, 95% CI: 0.771-1.720), BMI (OR = 0.998, 95% CI: 0.929-1.071), and number of co-morbidities (OR = 0.068, 95% CI: 0.088-1.093) did not show a significant relationship, and age at menarche (OR = 1.577, 95% CI: 1.031-2.412) showed a significant association with BP goal attainment among hypertensive postmenopausal women.
Half of the hypertensive postmenopausal women did not achieve their BP goals. Interventions are required to expand screening coverage and, under the direction of medical professionals, there should be plans to improve hypertension control and increase awareness of the condition.
在绝经后状态下，女性维持血压（BP）的方式可能与男性不同，尽管大多数女性比男性更严格地遵循治疗方案和处方。生物学和生活方式因素会影响绝经后女性（PMW）高血压的进展。本研究旨在确定与高血压绝经后女性实现血压目标相关的生物社会预测因素。
在印度喀拉拉邦卡鲁纳医学院医院的普通内科进行了一项前瞻性观察研究。根据2014年第八次美国国立综合癌症网络联合委员会（JNC VIII）概述的指南确定血压目标达成的定义。采用多变量逻辑回归分析来分析与血压目标达成相关的生物社会预测因素，如教育程度、就业状况、体重指数（BMI）、子女数量、初潮年龄、绝经年龄和合并症数量。
在这些患者中，56.4%的患者单药治疗实现了血压目标，59.7%的患者联合治疗实现了血压目标。教育程度[优势比（OR）=1.275，95%置信区间（CI）：0.234 - 7.172]、就业状况（OR = 0.853，95% CI：0.400 - 1.819）、绝经年龄（OR = 1.106，95% CI：0.881 - 1.149）、子女数量（OR = 1.152，95% CI：0.771 - 1.720）、BMI（OR = 0.998，95% CI：0.929 - 1.071）和合并症数量（OR = 0.068，95% CI：0.088 - 1.093）均未显示出显著关系，而初潮年龄（OR = 1.577，95% CI：1.031 - 2.412）在高血压绝经后女性中与血压目标达成显示出显著关联。
一半的高血压绝经后女性未实现其血压目标。需要采取干预措施扩大筛查范围，并且在医学专业人员的指导下，应有改善高血压控制和提高对该疾病认识的计划。
