Wu Yonghui, Yang Fujun, Luo Shilan, Li Xiang, Gu Zhan, Fan Rui, Cao Yajuan, Wang Lixin, Song Xiao
Department of Integrated Traditional Chinese and Western Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
Graduate School of Shanghai University of Traditional Chinese Medicine, Shanghai, China.
iScience. 2024 Feb 16;27(3):109258. doi: 10.1016/j.isci.2024.109258. eCollection 2024 Mar 15.
Brain metastases (BM) of lung adenocarcinoma (LUAD) are the most common intracranial malignancy leading to death. However, the cellular origins and drivers of BM from LUAD have not been clarified. Cellular composition was characterized by single-cell sequencing analysis of primary lung adenocarcinoma (pLUAD), BM and lymph node metastasis (LNM) samples in GSE131907. Our study briefly analyzed the tumor microenvironment (TME), focusing on the role of epithelial cells (ECs) in BM. We have discovered a population of brain metastasis-associated epithelial cells (BMAECs) expressing SPP1, SAA1, and CDKN2A, and it has been observed that this population is mainly composed of aneuploid cells from pLUAD, playing a crucial role in brain metastasis. Our study concluded that both LNM and BM in LUAD originated from pLUAD lesions, but there is currently insufficient evidence to prove a direct association between BM lesions and LNM lesions, which provides inspiration for further investigation of the TME in BM.
肺腺癌（LUAD）脑转移（BM）是导致死亡的最常见颅内恶性肿瘤。然而，LUAD脑转移的细胞起源和驱动因素尚未明确。通过对GSE131907中的原发性肺腺癌（pLUAD）、脑转移和淋巴结转移（LNM）样本进行单细胞测序分析，对细胞组成进行了表征。我们的研究简要分析了肿瘤微环境（TME），重点关注上皮细胞（ECs）在脑转移中的作用。我们发现了一群表达SPP1、SAA1和CDKN2A的脑转移相关上皮细胞（BMAECs），并且观察到这群细胞主要由来自pLUAD的非整倍体细胞组成，在脑转移中起关键作用。我们的研究得出结论，LUAD中的LNM和BM均起源于pLUAD病变，但目前尚无足够证据证明BM病变与LNM病变之间存在直接关联，这为进一步研究BM中的TME提供了启示。
