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颈动脉手术的短期疗效:单一教学中心的真实世界经验。

Short term outcomes of carotid surgery: the real-world experience of a single teaching center.

作者信息

Oliveira Tércio Ferreira, Centellas Carlos Diego Ribeiro, Dalio Marcelo Bellini, Joviliano Edwaldo Edner

机构信息

Universidade de São Paulo - USP, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, SP, Brasil.

出版信息

J Vasc Bras. 2024 Feb 5;23:e20230033. doi: 10.1590/1677-5449.202300332. eCollection 2024.

Abstract

BACKGROUND

Surgical treatment of symptomatic extracranial carotid stenosis is well established for preventing neurological events and should adhere to optimal quality standards. However, there is growing concern as to whether results of controlled trials are replicable in real-world settings.

OBJECTIVES

To assess a symptomatic carotid stenosis population that underwent surgery and its short-term outcomes in a real-world context at a professional training center.

METHODS

Observational study using data collected from medical records from January 2012 to January 2023. Patients undergoing operations for other carotid diseases and with concomitant heart surgery were excluded.

RESULTS

A total of 70 patients undergoing angioplasty or carotid endarterectomy were included. Population subsets undergoing angioplasty or endarterectomy were similar. Differences in anesthetic modality and a longer operative time in the carotid endarterectomy subgroup were statistically significant. There were 4 cases of stroke, only 3 of which (2 minor and 1 major) were related to the index lesion. Thus, the rate of major operation-related stroke was 1.43% and the rate of any lesion-related stroke was 4.29%. There was 1 case of AMI in the angioplasty group and there were no deaths in the sample. The overall rate of major adverse cardiovascular events was 5.71%. There were no statistical differences between the endarterectomy and angioplasty groups regarding the main outcomes.

CONCLUSIONS

The rates of outcomes of ischemic stroke, acute myocardial infarction, death, and major adverse cardiovascular events at this center are in line with the rates reported by randomized controlled trials, demonstrating the feasibility of carotid surgery in centers with teaching programs.

摘要

背景

有症状的颅外颈动脉狭窄的外科治疗在预防神经事件方面已得到充分确立,且应遵循最佳质量标准。然而,对于对照试验的结果在现实环境中是否可复制,人们的担忧日益增加。

目的

在一个专业培训中心的现实环境中,评估接受手术治疗的有症状颈动脉狭窄人群及其短期结局。

方法

采用观察性研究,使用2012年1月至2023年1月从医疗记录中收集的数据。排除因其他颈动脉疾病接受手术以及同时进行心脏手术的患者。

结果

共纳入70例行血管成形术或颈动脉内膜切除术的患者。接受血管成形术或内膜切除术的人群亚组相似。颈动脉内膜切除术亚组在麻醉方式和手术时间较长方面的差异具有统计学意义。有4例中风,其中仅3例(2例轻度和1例重度)与索引病变相关。因此,主要手术相关中风发生率为1.43%,任何病变相关中风发生率为4.29%。血管成形术组有1例急性心肌梗死,样本中无死亡病例。主要不良心血管事件的总体发生率为5.71%。内膜切除术组和血管成形术组在主要结局方面无统计学差异。

结论

该中心缺血性中风、急性心肌梗死、死亡和主要不良心血管事件的结局发生率与随机对照试验报告的发生率一致,表明在有教学项目的中心进行颈动脉手术是可行的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c430/10903515/c18032178bbe/jvb-23-e20230033-g01-en.jpg

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