Waluyo Setyo Teguh, Tjokroprawiro Brahmana Askandar, Rahaju Anny Setijo
Subspecialist Education Program, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Dr. Soetomo General Academic Hospital, Medical Faculty -Universitas Airlangga, Surabaya, Indonesia.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga/Dr.Soetomo General Academic Hospital, Surabaya, Indonesia.
Eur J Obstet Gynecol Reprod Biol X. 2024 Feb 20;21:100293. doi: 10.1016/j.eurox.2024.100293. eCollection 2024 Mar.
To determine the effect of estrogen receptor (ER) on programmed death-ligand 1 (PD-L1) expression in type I endometrial cancer (EC).
This retrospective study included 85 patients with type I EC who underwent surgery at Dr. Soetomo Hospital between 2018 and 2022. A random sampling technique was employed. Immunohistochemistry (IHC) with ER and PD-L1 antibodies was performed on all samples. In this study, ER expression served as the independent variable, while PD-L1 expression was considered the dependent variable. Data analysis was performed using Spearman's rank correlation coefficient test.
Out of the 85 patients with type I EC, 58 (68.2%) exhibited positive and 27 (31.8%) exhibited negative ER expression. Meanwhile positive PD-L1 expression was seen in 67 (78.8%) and 18 (21.2%) exhibited negative PD-L1 expression. The study revealed a strong negative correlation between ER and PD-L1 expression in EC (rho value = -0.886, p-value = 0.0001).
ER downregulates PD-L1 in type I EC. The findings of this study can be used as reference data and as the basis for further research, especially investigations of the prognostic and immunotherapeutic value of ER and PD-L1 expression in type I EC.
确定雌激素受体（ER）对I型子宫内膜癌（EC）中程序性死亡配体1（PD-L1）表达的影响。
这项回顾性研究纳入了2018年至2022年间在苏托莫博士医院接受手术的85例I型EC患者。采用随机抽样技术。对所有样本进行ER和PD-L1抗体的免疫组织化学（IHC）检测。在本研究中，ER表达作为自变量，而PD-L1表达被视为因变量。使用Spearman等级相关系数检验进行数据分析。
在85例I型EC患者中，58例（68.2%）ER表达阳性，27例（31.8%）ER表达阴性。同时，67例（78.8%）PD-L1表达阳性，18例（21.2%）PD-L1表达阴性。研究显示EC中ER与PD-L1表达之间存在强负相关（rho值 = -0.886，p值 = 0.0001）。
ER下调I型EC中的PD-L1。本研究结果可作为参考数据，并作为进一步研究的基础，特别是对I型EC中ER和PD-L1表达的预后和免疫治疗价值的研究。
