Li Zhen, Li Wenqiang, Li Yuanyuan, Ma Fubing, Li Guangjuan
Department of ICU, Jining No.1 People's Hospital, Jining, China.
Jining Skin Disease Prevention and Treatment Hospital, Jining, China.
Heliyon. 2024 Feb 22;10(5):e26905. doi: 10.1016/j.heliyon.2024.e26905. eCollection 2024 Mar 15.
amoebic encephalitis (BAE) is a rare and severe parasitic infection of the central nervous system. Its delayed diagnosis and treatment are often due to the lack of specific clinical manifestations and its poor prognosis. Reported mortality rates reach around 95%. The Balamuthia mandrillaris is also known as the "brain-eating amoeba." Recently, the use of metagenomic next-generation sequencing (mNGS) in clinical settings has led to an increase in BAE diagnoses. A case report detailing the use of mNGS to diagnose granulomatous encephalitis caused by the Baramsi amoeba has improved clinicians' understanding of this disease and helped reduce misdiagnoses and missed diagnoses.
巴拉姆希阿米巴脑炎（BAE）是一种罕见且严重的中枢神经系统寄生虫感染。其诊断和治疗的延迟往往是由于缺乏特异性临床表现以及预后较差。报告的死亡率约为95%。曼氏巴通体也被称为“食脑变形虫”。最近，宏基因组下一代测序（mNGS）在临床环境中的应用导致BAE诊断数量增加。一份详细描述使用mNGS诊断巴拉姆希阿米巴引起的肉芽肿性脑炎的病例报告，提高了临床医生对这种疾病的认识，并有助于减少误诊和漏诊。
