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基于血浆的下一代测序检测对脑炎的快速、无创诊断

Rapid, Noninvasive Diagnosis of Encephalitis by a Plasma-Based Next-Generation Sequencing Test.

作者信息

Kalyatanda Gautam, Rand Kenneth, Lindner Martin S, Hong David K, Sait Albayram Mehmet, Gregory Jason, Kresak Jesse, Ibne Karim M Ali, Cope Jennifer R, Roy Shantanu, Gary Joy M, Reddy Varalakshmi, Ahmed Asim A

机构信息

Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.

出版信息

Open Forum Infect Dis. 2020 Jun 1;7(7):ofaa189. doi: 10.1093/ofid/ofaa189. eCollection 2020 Jul.

DOI:10.1093/ofid/ofaa189
PMID:32715017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7371414/
Abstract

Granulomatous amoebic encephalitis (GAE) caused by is a rare subacute infection with exceptionally high mortality. Diagnosis is typically made by brain biopsy or at autopsy. Detection of cell-free DNA by next-generation sequencing of plasma enabled rapid, noninvasive diagnosis in a case of amoebic encephalitis.

摘要

由 引起的肉芽肿性阿米巴脑炎（GAE）是一种罕见的亚急性感染，死亡率极高。诊断通常通过脑活检或尸检进行。在一例阿米巴脑炎病例中，通过血浆的下一代测序检测无细胞DNA实现了快速、非侵入性诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b7/7371414/40fe74bd8321/ofaa189f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b7/7371414/48271d2723c1/ofaa189f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b7/7371414/40fe74bd8321/ofaa189f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b7/7371414/48271d2723c1/ofaa189f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00b7/7371414/40fe74bd8321/ofaa189f0002.jpg

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Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis.临床宏基因组测序在脑膜炎和脑炎诊断中的应用。
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Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease.微生物无细胞 DNA 测序检测用于感染性疾病的分析和临床验证。
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