Abuqwider Jumana, Altamimi Mohammad, Mauriello Gianluigi
Department of Agricultural Science, University of Naples Federico II, 80049 Naples, Italy.
Department of Nutrition and Food Technology, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus P.O. Box 7, Palestine.
Microorganisms. 2022 Feb 28;10(3):522. doi: 10.3390/microorganisms10030522.
is a microorganism with valuable probiotic qualities that has been widely employed in humans to promote health. It is a well-studied probiotic bacterium that exerts beneficial health effects due to several metabolic mechanisms that enhance the production of anti-inflammatory cytochines and modulate the gut microbiota by the production of antimicrobial molecules, including reuterin. This review provides an overview of the data that support the role of probiotic properties, and the antimicrobial and immunomodulatory effects of some strains in relation to their metabolite production profile on the amelioration of many diseases and disorders. Although the results discussed in this paper are strain dependent, they show that , by different mechanisms and various metabolites, may control body weight and obesity, improve insulin sensitivity and glucose homeostasis, increase gut integrity and immunomodulation, and attenuate hepatic disorders. Gut microbiota modulation by ingesting probiotic strains could be a promising preventative and therapeutic approach against many diseases and disorders.
是一种具有宝贵益生菌特性的微生物，已在人类中广泛用于促进健康。它是一种经过充分研究的益生菌，由于多种代谢机制而发挥有益的健康作用，这些机制可增强抗炎细胞因子的产生，并通过产生包括罗伊氏菌素在内的抗菌分子来调节肠道微生物群。本综述概述了支持益生菌特性作用的数据，以及某些菌株在其代谢产物产生概况方面对改善多种疾病和病症的抗菌和免疫调节作用。尽管本文讨论的结果因菌株而异，但它们表明，通过不同的机制和各种代谢产物，可能控制体重和肥胖、改善胰岛素敏感性和葡萄糖稳态、增强肠道完整性和免疫调节，并减轻肝脏疾病。通过摄入益生菌菌株来调节肠道微生物群可能是针对多种疾病和病症的一种有前途的预防和治疗方法。
