• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Syrosingopine, an anti-hypertensive drug and lactate transporter (MCT1/4) inhibitor, activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model.

作者信息

Guo Meichun, Gou Yannian, Dong Xiangyu, Zhong Jiamin, Li Aohua, Hao Ailing, He Tong-Chuan, Fan Jiaming

机构信息

Ministry of Education Key Laboratory of Diagnostic Medicine, and the School of Laboratory Diagnostic Medicine, Chongqing Medical University, Chongqing 400016, China.

Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL 60637, USA.

出版信息

Genes Dis. 2023 Nov 18;11(4):101169. doi: 10.1016/j.gendis.2023.101169. eCollection 2024 Jul.

DOI:10.1016/j.gendis.2023.101169
PMID:38434753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10909599/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee3/10909599/0f7065bc15c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee3/10909599/0f7065bc15c8/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee3/10909599/0f7065bc15c8/gr1.jpg

相似文献

1
Syrosingopine, an anti-hypertensive drug and lactate transporter (MCT1/4) inhibitor, activates hepatic stellate cells and exacerbates liver fibrosis in a mouse model.辛可宁平是一种抗高血压药物和乳酸转运体（MCT1/4）抑制剂，在小鼠模型中可激活肝星状细胞并加剧肝纤维化。
Genes Dis. 2023 Nov 18;11(4):101169. doi: 10.1016/j.gendis.2023.101169. eCollection 2024 Jul.
2
Metformin confers sensitisation to syrosingopine in multiple myeloma cells by metabolic blockage and inhibition of protein synthesis.二甲双胍通过代谢阻断和抑制蛋白质合成，使多发性骨髓瘤细胞对玫瑰树碱敏感。
J Pathol. 2023 Jun;260(2):112-123. doi: 10.1002/path.6066. Epub 2023 Mar 28.
3
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.乳酸转运蛋白 MCT1 和 MCT4 的双重抑制与二甲双胍联合使用具有合成致死性，这是由于癌细胞中 NAD+ 的耗竭。
Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043.
4
Targeting Lactate Metabolism by Inhibiting MCT1 or MCT4 Impairs Leukemic Cell Proliferation, Induces Two Different Related Death-Pathways and Increases Chemotherapeutic Sensitivity of Acute Myeloid Leukemia Cells.通过抑制单羧酸转运蛋白1（MCT1）或单羧酸转运蛋白4（MCT4）靶向乳酸代谢会损害白血病细胞增殖，诱导两种不同的相关死亡途径，并增加急性髓系白血病细胞的化疗敏感性。
Front Oncol. 2021 Feb 5;10:621458. doi: 10.3389/fonc.2020.621458. eCollection 2020.
5
Monocarboxylate transporter 1 in the liver modulates high-fat diet-induced obesity and hepatic steatosis in mice.肝脏中的单羧酸转运蛋白 1 调节高脂肪饮食诱导的肥胖和肝脂肪变性。
Metabolism. 2023 Jun;143:155537. doi: 10.1016/j.metabol.2023.155537. Epub 2023 Mar 17.
6
Transforming growth factor beta-1 upregulates glucose transporter 1 and glycolysis through canonical and noncanonical pathways in hepatic stellate cells.转化生长因子-β1 通过经典和非经典途径上调肝星状细胞中的葡萄糖转运蛋白 1 和糖酵解。
World J Gastroenterol. 2021 Oct 28;27(40):6908-6926. doi: 10.3748/wjg.v27.i40.6908.
7
Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification.评价MCT抑制剂辛可宁平作为肿瘤代谢和细胞外酸化潜在调节剂的作用。
Metabolites. 2022 Jun 17;12(6):557. doi: 10.3390/metabo12060557.
8
Deregulation of energy metabolism promotes antifibrotic effects in human hepatic stellate cells and prevents liver fibrosis in a mouse model.能量代谢失调促进人肝星状细胞的抗纤维化作用，并在小鼠模型中预防肝纤维化。
Biochem Biophys Res Commun. 2016 Jan 15;469(3):463-9. doi: 10.1016/j.bbrc.2015.10.101. Epub 2015 Oct 23.
9
Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.DNMT1 和 DNMT3b 介导的 RCAN1.4 甲基化通过钙调神经磷酸酶/NFAT3 信号增强肝星状细胞激活和肝纤维化。
Theranostics. 2019 Jun 9;9(15):4308-4323. doi: 10.7150/thno.32710. eCollection 2019.
10
Activated Hepatic Stellate Cells Promote the M1 to M2 Macrophage Transformation and Liver Fibrosis by Elevating the Histone Acetylation Level.活化的肝星状细胞通过提高组蛋白乙酰化水平促进 M1 向 M2 巨噬细胞转化和肝纤维化。
Dis Markers. 2022 Sep 12;2022:9883831. doi: 10.1155/2022/9883831. eCollection 2022.

引用本文的文献

1
Lactylation modification in lung cancer: A review of current research and future directions (Review).肺癌中的乳酸化修饰：当前研究与未来方向综述（综述）
Oncol Rep. 2025 Nov;54(5). doi: 10.3892/or.2025.8981. Epub 2025 Sep 5.
2
Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases.靶向乳酰化：从代谢重编程到肝脏疾病的精准治疗
Biomolecules. 2025 Aug 16;15(8):1178. doi: 10.3390/biom15081178.
3
Lactylation modifications in urological diseases: molecular mechanisms and biological implications.

本文引用的文献

1
Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells.乳酸转运蛋白 MCT1 和 MCT4 的双重抑制与二甲双胍联合使用具有合成致死性，这是由于癌细胞中 NAD+ 的耗竭。
Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. doi: 10.1016/j.celrep.2018.11.043.
2
Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues.肝纤维化：病理生理学、发病机制靶点和临床问题。
Mol Aspects Med. 2019 Feb;65:37-55. doi: 10.1016/j.mam.2018.09.002. Epub 2018 Sep 13.
3
Hepatic stellate cells as key target in liver fibrosis.
泌尿系统疾病中的乳酸化修饰：分子机制与生物学意义
Clin Epigenetics. 2025 Aug 6;17(1):139. doi: 10.1186/s13148-025-01947-4.
4
Lactate and lactylation: novel perspectives on fibrosis pathogenesis and therapeutic directions.乳酸与乳酸化：纤维化发病机制及治疗方向的新视角
J Transl Med. 2025 Jul 1;23(1):705. doi: 10.1186/s12967-025-06748-0.
5
Lactate transporter MCT4 regulates the hub genes for lipid metabolism and inflammation to attenuate intracellular lipid accumulation in non-alcoholic fatty liver disease.乳酸转运体MCT4通过调节脂质代谢和炎症的枢纽基因来减轻非酒精性脂肪性肝病中的细胞内脂质积累。
Genes Dis. 2025 Feb 15;12(4):101554. doi: 10.1016/j.gendis.2025.101554. eCollection 2025 Jul.
6
Lactate and Lactylation: Dual Regulators of T-Cell-Mediated Tumor Immunity and Immunotherapy.乳酸与乳酸化：T细胞介导的肿瘤免疫及免疫治疗的双重调节因子
Biomolecules. 2024 Dec 21;14(12):1646. doi: 10.3390/biom14121646.
7
Effective Bone Tissue Fabrication Using 3D-Printed Citrate-Based Nanocomposite Scaffolds Laden with BMP9-Stimulated Human Urine Stem Cells.使用负载BMP9刺激的人尿干细胞的3D打印柠檬酸盐基纳米复合支架进行有效的骨组织制造
ACS Appl Mater Interfaces. 2025 Jan 8;17(1):197-210. doi: 10.1021/acsami.4c13246. Epub 2024 Dec 24.
8
GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus.甘油醛-3-磷酸脱氢酶可抑制腺病毒诱导的氧化应激，并实现重组腺病毒的超快速生产。
Genes Dis. 2024 May 31;11(6):101344. doi: 10.1016/j.gendis.2024.101344. eCollection 2024 Nov.
9
Establishment and characterization of a rat model of scalp-cranial composite defect for multilayered tissue engineering.用于多层组织工程的大鼠头皮-颅骨复合缺损模型的建立与表征
Res Sq. 2024 Jul 23:rs.3.rs-4643966. doi: 10.21203/rs.3.rs-4643966/v1.
10
Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering.脂肪来源的间充质干细胞是骨组织工程的优质细胞来源。
Bioact Mater. 2023 Dec 14;34:51-63. doi: 10.1016/j.bioactmat.2023.12.003. eCollection 2024 Apr.
肝星状细胞作为肝纤维化的关键靶点。
Adv Drug Deliv Rev. 2017 Nov 1;121:27-42. doi: 10.1016/j.addr.2017.05.007. Epub 2017 May 12.
4
Syrosingopine sensitizes cancer cells to killing by metformin.西洛辛碱使癌细胞对二甲双胍的杀伤作用敏感。
Sci Adv. 2016 Dec 23;2(12):e1601756. doi: 10.1126/sciadv.1601756. eCollection 2016 Dec.