• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

结直肠癌的皮肤转移:一种罕见且被忽视的现象。

Cutaneous Metastasis in Colorectal Cancer: A Rare and Overlooked Phenomenon.

作者信息

Okafor Chinedum

机构信息

Pathology, Louisiana State University Health System, Shreveport, USA.

出版信息

Cureus. 2024 Feb 2;16(2):e53437. doi: 10.7759/cureus.53437. eCollection 2024 Feb.

DOI:10.7759/cureus.53437
PMID:38435210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10909233/
Abstract

Cutaneous metastasis from internal malignancies, indicative of poor prognosis, is rare and often involves primary sources like lung, breast, and colorectal cancer (CRC). This case details a 66-year-old male developing a scalp lesion 10 years post colon adenocarcinoma diagnosis. The challenging medical journey included a comprehensive biopsy confirming metastatic CRC in cutaneous tissue through CDX2 and CK20 positivity, emphasizing the importance of advanced diagnostic techniques. Despite medical advancements, the patient's unfavorable prognosis led to succumbing within a year, highlighting challenges in managing such cases and the need for vigilant post-diagnosis care. This report underscores the limited understanding of cutaneous metastasis, emphasizing the role of immunostaining and prompting awareness for early detection and tailored treatment. Further research into atypical metastasis mechanisms is crucial for improved prognostic outcomes and enhanced comprehension of these complex manifestations.

摘要

来自内部恶性肿瘤的皮肤转移罕见,提示预后不良,且常涉及肺、乳腺和结直肠癌(CRC)等原发部位。本病例详细介绍了一名66岁男性,在结肠癌腺癌诊断10年后出现头皮病变。充满挑战的就医过程包括全面活检,通过CDX2和CK20阳性证实皮肤组织中存在转移性CRC,强调了先进诊断技术的重要性。尽管医学取得了进步,但患者预后不佳,在一年内死亡,凸显了处理此类病例的挑战以及诊断后密切护理的必要性。本报告强调了对皮肤转移的认识有限,强调了免疫染色的作用,并促使人们提高对早期检测和个性化治疗的认识。对非典型转移机制的进一步研究对于改善预后结果和增强对这些复杂表现的理解至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/388a0e868364/cureus-0016-00000053437-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/d5ed2376839a/cureus-0016-00000053437-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/97bcb53cd9f4/cureus-0016-00000053437-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/571ed53928ee/cureus-0016-00000053437-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/388a0e868364/cureus-0016-00000053437-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/d5ed2376839a/cureus-0016-00000053437-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/97bcb53cd9f4/cureus-0016-00000053437-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/571ed53928ee/cureus-0016-00000053437-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/388a0e868364/cureus-0016-00000053437-i04.jpg

相似文献

1
Cutaneous Metastasis in Colorectal Cancer: A Rare and Overlooked Phenomenon.结直肠癌的皮肤转移:一种罕见且被忽视的现象。
Cureus. 2024 Feb 2;16(2):e53437. doi: 10.7759/cureus.53437. eCollection 2024 Feb.
2
Folliculotropic Cutaneous Metastases and Lymphangitis Carcinomatosa: When Cutaneous Metastases of Breast Carcinoma Are Mistaken for Cutaneous Infections.毛囊性皮肤转移瘤和癌性淋巴管炎:乳腺癌皮肤转移被误诊为皮肤感染时的情况。
Acta Dermatovenerol Croat. 2016 Jun;24(2):154-7.
3
Cutaneous Limb Metastasis of Colorectal Cancer Misdiagnosed as Zoster Infection.误诊为带状疱疹感染的结直肠癌皮肤肢体转移
Cureus. 2023 Mar 24;15(3):e36621. doi: 10.7759/cureus.36621. eCollection 2023 Mar.
4
Cutaneous and breast metastasis from colorectal adenocarcinoma: A rare case report.结直肠癌的皮肤及乳腺转移:1例罕见病例报告
Mol Clin Oncol. 2019 Aug;11(2):143-146. doi: 10.3892/mco.2019.1866. Epub 2019 May 24.
5
Cutaneous Metastasis of Transverse Colon Cancer with an Aberrant Pattern of CK7/CK20/CDX2 and High Microsatellite Instability.结直肠癌 CK7/CK20/CDX2 异常表达模式伴高微卫星不稳定的皮肤转移
Intern Med. 2023 Dec 15;62(24):3625-3630. doi: 10.2169/internalmedicine.1629-23. Epub 2023 May 10.
6
Gastric Cardia Adenocarcinoma with Metastasis to the Scalp: A Case Report.胃贲门腺癌伴头皮转移:一例报告
Cureus. 2020 Jan 27;12(1):e6781. doi: 10.7759/cureus.6781.
7
Primary ascending colon cancer accompanying skip metastases in left shoulder skin and left neck lymph node: A case report.原发性升结肠癌伴左肩部皮肤及左颈部淋巴结跳跃转移:一例报告。
World J Clin Cases. 2022 Aug 16;10(23):8262-8270. doi: 10.12998/wjcc.v10.i23.8262.
8
Multiple Cutaneous Metastases as Initial Presentation in Advanced Colon Cancer.多发皮肤转移作为晚期结肠癌的首发表现
Case Rep Gastrointest Med. 2018 Apr 30;2018:8032905. doi: 10.1155/2018/8032905. eCollection 2018.
9
Cutaneous metastasis to the face from colon adenocarcinoma. Case report.结肠癌皮肤转移至面部。病例报告。
Int Semin Surg Oncol. 2006 Feb 2;3:2. doi: 10.1186/1477-7800-3-2.
10
Cutaneous Metastasis of Sigmoid Adenocarcinoma to Face and Scalp at Initial Diagnosis: Case Report.乙状结肠腺癌初诊时面部及头皮皮肤转移:病例报告
Gulf J Oncolog. 2018 May;1(27):70-72.

引用本文的文献

1
Partial response to posterior line immunotherapy for more than 15 months in a pMMR patient with cutaneous metastasis of rectal carcinoma: a case report.错配修复蛋白缺陷(pMMR)的直肠癌皮肤转移患者对后线免疫治疗产生超过15个月的部分缓解:一例病例报告
Therap Adv Gastroenterol. 2025 May 8;18:17562848251338673. doi: 10.1177/17562848251338673. eCollection 2025.

本文引用的文献

1
Unusual Cutaneous Metastases From Colon Adenocarcinoma.来自结肠腺癌的罕见皮肤转移瘤
Cureus. 2021 Mar 23;13(3):e14065. doi: 10.7759/cureus.14065.
2
Large single cutaneous metastasis of colon adenocarcinoma mimicking a squamous cell carcinoma of the skin: A case report.酷似皮肤鳞状细胞癌的结肠腺癌单发性巨大皮肤转移瘤:1例报告
Int J Surg Case Rep. 2019;56:96-100. doi: 10.1016/j.ijscr.2019.02.043. Epub 2019 Mar 7.
3
Sister Mary Joseph's nodule as a diagnostic clue to metastatic colon carcinoma.玛丽·约瑟夫修女结节作为转移性结肠癌的诊断线索。
J Clin Oncol. 2009 Jul 1;27(19):e1-2. doi: 10.1200/JCO.2009.22.1515. Epub 2009 May 11.
4
Cutaneous manifestations of internal malignancy: diagnosis and management.内部恶性肿瘤的皮肤表现:诊断与管理
Am J Clin Dermatol. 2006;7(2):71-84. doi: 10.2165/00128071-200607020-00001.
5
Cutaneous metastasis to the face from colon adenocarcinoma. Case report.结肠癌皮肤转移至面部。病例报告。
Int Semin Surg Oncol. 2006 Feb 2;3:2. doi: 10.1186/1477-7800-3-2.
6
Cutaneous metastasis: a meta-analysis of data.皮肤转移:数据的荟萃分析
South Med J. 2003 Feb;96(2):164-7. doi: 10.1097/01.SMJ.0000053676.73249.E5.
7
Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients.转移性癌患者的皮肤转移:对4020例患者的回顾性研究
J Am Acad Dermatol. 1993 Aug;29(2 Pt 1):228-36. doi: 10.1016/0190-9622(93)70173-q.