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结直肠癌的皮肤转移:一种罕见且被忽视的现象。

Cutaneous Metastasis in Colorectal Cancer: A Rare and Overlooked Phenomenon.

作者信息

Okafor Chinedum

机构信息

Pathology, Louisiana State University Health System, Shreveport, USA.

出版信息

Cureus. 2024 Feb 2;16(2):e53437. doi: 10.7759/cureus.53437. eCollection 2024 Feb.

Abstract

Cutaneous metastasis from internal malignancies, indicative of poor prognosis, is rare and often involves primary sources like lung, breast, and colorectal cancer (CRC). This case details a 66-year-old male developing a scalp lesion 10 years post colon adenocarcinoma diagnosis. The challenging medical journey included a comprehensive biopsy confirming metastatic CRC in cutaneous tissue through CDX2 and CK20 positivity, emphasizing the importance of advanced diagnostic techniques. Despite medical advancements, the patient's unfavorable prognosis led to succumbing within a year, highlighting challenges in managing such cases and the need for vigilant post-diagnosis care. This report underscores the limited understanding of cutaneous metastasis, emphasizing the role of immunostaining and prompting awareness for early detection and tailored treatment. Further research into atypical metastasis mechanisms is crucial for improved prognostic outcomes and enhanced comprehension of these complex manifestations.

摘要

来自内部恶性肿瘤的皮肤转移罕见,提示预后不良,且常涉及肺、乳腺和结直肠癌(CRC)等原发部位。本病例详细介绍了一名66岁男性,在结肠癌腺癌诊断10年后出现头皮病变。充满挑战的就医过程包括全面活检,通过CDX2和CK20阳性证实皮肤组织中存在转移性CRC,强调了先进诊断技术的重要性。尽管医学取得了进步,但患者预后不佳,在一年内死亡,凸显了处理此类病例的挑战以及诊断后密切护理的必要性。本报告强调了对皮肤转移的认识有限,强调了免疫染色的作用,并促使人们提高对早期检测和个性化治疗的认识。对非典型转移机制的进一步研究对于改善预后结果和增强对这些复杂表现的理解至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/953a/10909233/d5ed2376839a/cureus-0016-00000053437-i01.jpg

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