Lin Yugui, Li Yanfen, Lin Chunxiu
Microbiology Laboratory, Zhongshan Bo'ai Hospital, Zhongshan, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China.
Front Cell Infect Microbiol. 2024 Feb 16;14:1280188. doi: 10.3389/fcimb.2024.1280188. eCollection 2024.
Human infections caused by , an environmental bacterium, are infrequent, with only two cases related to uncommon urinary tract infections and bacteremia reported in recent years. All these cases typically occurred in elderly patients with compromised or decreased immune function. Simultaneously, the epithelial barrier disruption induced by invasive biopsy procedures or gastrointestinal disorders such as gastroenteritis provided a pathway for to infiltrate the organism. In this study, we present the first report of a case where and were isolated from the inflamed appendix of a patient without underlying conditions. Compared to the , has never been isolated in patients with appendicitis. We identified the species using MALDI-TOF MS and genetic sequencing. Based on our findings, we highlight the perspective that can colonize the intestines of healthy individuals and may trigger infections like appendicitis.
由一种环境细菌引起的人类感染并不常见，近年来仅报告了两例与罕见的尿路感染和菌血症相关的病例。所有这些病例通常发生在免疫功能受损或下降的老年患者中。同时，侵入性活检程序或胃肠道疾病（如肠胃炎）引起的上皮屏障破坏为该细菌渗透机体提供了途径。在本研究中，我们首次报告了一例从无基础疾病患者的发炎阑尾中分离出该细菌和另一种细菌的病例。与另一种细菌相比，该细菌从未在阑尾炎患者中分离出来。我们使用基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）和基因测序鉴定了该菌种。基于我们的发现，我们强调了该细菌可以在健康个体的肠道中定殖并可能引发阑尾炎等感染的观点。
