Zhao Yinying, Zhao Qihui, Zhang Hongfang, Zhang Zhewen, Wang Dandan, Li Zhangliang, Ding Xixia, Zhao Yune
The School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.
National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China.
Front Med (Lausanne). 2024 Feb 16;11:1301588. doi: 10.3389/fmed.2024.1301588. eCollection 2024.
To investigate the characteristic cytokine profile of the aqueous humor in eyes with congenital cataract and pre-existing posterior capsule dysfunction (PCD).
In this cross-sectional study, the enrolled eyes with congenital cataract and PCD were included in the PCD group, while those with an intact posterior capsule were included in the control group. Demographic data and biometric parameters were recorded. The levels of 17 inflammatory factors in the aqueous humor collected from the enrolled eyes were detected using Luminex xMAP technology, and intergroup differences in the collected data were analyzed.
The PCD group comprised 41 eyes from 31 patients with congenital cataract and PCD, whereas the control group comprised 42 eyes from 27 patients with congenital cataract and an intact posterior capsule. Lens thickness was significantly thinner in the PCD group than in the control group. However, the levels of monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-β2 (TGF-β2), and vascular endothelial growth factor (VEGF) were significantly higher in the PCD group than in the control group. Multivariate logistic regression confirmed that lens thickness and TGF-β2 level were independent risk factors for PCD.
A thinner lens thickness in eyes with congenital cataract and PCD could serve as a biometric feature of these eyes. The higher levels of MCP-1, TGF-β2, and VEGF in eyes with PCD indicated a change in their intraocular inflammatory microenvironment, which possibly led to cataract progression. Lens thickness and TGF-β2 level are independent risk factors for PCD.
研究先天性白内障合并既往后囊膜功能障碍（PCD）患者眼房水的特征性细胞因子谱。
在这项横断面研究中，将纳入的先天性白内障合并PCD的眼纳入PCD组，而后囊膜完整的眼纳入对照组。记录人口统计学数据和生物测量参数。使用Luminex xMAP技术检测从纳入的眼中收集的房水中17种炎症因子的水平，并分析收集数据的组间差异。
PCD组包括31例先天性白内障合并PCD患者的41只眼，而对照组包括27例先天性白内障且后囊膜完整患者的42只眼。PCD组的晶状体厚度明显比对照组薄。然而，PCD组中单核细胞趋化蛋白-1（MCP-1）、转化生长因子-β2（TGF-β2）和血管内皮生长因子（VEGF）的水平明显高于对照组。多因素逻辑回归证实晶状体厚度和TGF-β2水平是PCD的独立危险因素。
先天性白内障合并PCD患者较薄的晶状体厚度可作为这些眼的生物测量特征。PCD患者眼中较高水平的MCP-1、TGF-β2和VEGF表明其眼内炎症微环境发生了变化，这可能导致白内障进展。晶状体厚度和TGF-β2水平是PCD的独立危险因素。
