Abdel-Rahman Ibrahim, Alharbi Abdulhamid Awadh, Alsaedi Maryam Zain, Alharbi Noof Mejzi Alamri, Al-Mughassil Sajidah Basheer, Al-Bahar Zainab Anwar, Donkol Abdel-Raheem, Baghdadi Hussam, Alanzi Mariam Eid, El Sayed Salah Mohamed
Department of Surgery, Faculty of Medicine, Al-Rayyan Medical Colleges, Al-Madinah Al-Munawwarah, SAU.
Department of General Surgery, Obesity Center, King Fahad General Hospital, Al-Madinah Al-Munawwarah, SAU.
Cureus. 2024 Jan 31;16(1):e53295. doi: 10.7759/cureus.53295. eCollection 2024 Jan.
The prevalence of obesity has increased globally and is associated with many comorbidities such as type 2 diabetes and fatty liver and cardiovascular diseases. Bariatric surgery is considered an effective intervention for achieving weight loss and controlling lipidemia and glycemia.
This Saudi retrospective observational study evaluates the clinical and biochemical benefits following bariatric surgery to obese diabetic patients. Methodology: After gaining ethical committee approval, data was collected from the patients' medical records at a tertiary medical center (King Fahad General Hospital, Al-Madinah Al-Munawwarah, Saudi Arabia). The total sample size was 61 patients, of whom 78.33% (n=48) had a body mass index (BMI) of 40 or greater (obese class III).
Following bariatric surgery, there were statistically significant reductions (p<0.001) in BMI and HbA1C (decreased from 45.53±7.791 kg/m and 7.9±1.82% to 33.42±6.18 kg/m and 6.06±1.35%, respectively, after surgery). Likewise, significant reductions (p<0.001) occurred to serum total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides that decreased from 234.4±26.7 mg/dl, 152.2±19.4 mg/dl, and 187.3±24.6 mg/dl to 158.4±17.3 mg/dl, 95.6±15.7 mg/dl, and 132.5±19.5 mg/dl, respectively. Interestingly, serum high-density lipoprotein (HDL) significantly increased (p<0.001) from 43.8±6.2 mg/dl to 52.3±4.6 mg/dl. Using the novel clinical therapeutic index, bariatric surgery decreased BMI by about 26.6%. Using the novel biochemical therapeutic index, bariatric surgery decreased HbA1C, serum total cholesterol, serum LDL cholesterol, and serum triglycerides by about 22.99%, 32.42%, 37.18%, and 29.26%, respectively, while serum HDL increased by about 19.4%.
Bariatric surgery is an effective intervention for obese diabetic patients resulting in weight loss, better control of diabetes and hyperlipidemia, and the metabolic profile. It is also recommended in Saudi Arabia for the high prevalence of obesity and diabetes mellitus.
肥胖症在全球范围内的患病率有所上升，且与许多合并症相关，如2型糖尿病、脂肪肝和心血管疾病。减肥手术被认为是实现体重减轻以及控制血脂和血糖的有效干预措施。
这项沙特回顾性观察性研究评估了减肥手术对肥胖糖尿病患者的临床和生化益处。
在获得伦理委员会批准后，从一家三级医疗中心（沙特阿拉伯麦地那穆纳瓦拉市法赫德国王总医院）的患者病历中收集数据。总样本量为61例患者，其中78.33%（n = 48）的体重指数（BMI）为40或更高（III级肥胖）。
减肥手术后，BMI和糖化血红蛋白（HbA1C）有统计学意义的降低（p<0.001）（术后分别从45.53±7.791kg/m²和7.9±1.82%降至33.42±6.18kg/m²和6.06±1.35%）。同样，血清总胆固醇、低密度脂蛋白（LDL）胆固醇和甘油三酯也有显著降低（p<0.001），分别从234.4±26.7mg/dl、152.2±19.4mg/dl和187.3±24.6mg/dl降至158.4±17.3mg/dl、95.6±15.7mg/dl和132.5±19.5mg/dl。有趣的是，血清高密度脂蛋白（HDL）显著升高（p<0.001），从43.8±6.2mg/dl升至52.3±4.6mg/dl。使用新的临床治疗指数，减肥手术使BMI降低了约26.6%。使用新的生化治疗指数，减肥手术使HbA1C、血清总胆固醇、血清LDL胆固醇和血清甘油三酯分别降低了约22.99%、32.42%、37.18%和29.26%，而血清HDL升高了约19.4%。
减肥手术是肥胖糖尿病患者的有效干预措施，可导致体重减轻、更好地控制糖尿病和高脂血症以及改善代谢状况。鉴于沙特阿拉伯肥胖症和糖尿病的高患病率，减肥手术也被推荐使用。
