Ahmed Anwar E, Alanazi Wala R, Ahmed Rayan A, AlJohi Wijdan, AlBuraikan Doaa A, AlRasheed Budor A, ALMuqbil Bashayr I, Al-Zahrani Ali A, Yousef Zeyad M, Al-Jahdali Hamdan
King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Diabetes Metab Syndr Obes. 2018 Jun 12;11:271-276. doi: 10.2147/DMSO.S161540. eCollection 2018.
Although the frequency of surgical weight loss interventions has increased in Saudi Arabia, literature describing the clinical outcomes of bariatric surgery in Saudi Arabia is limited. This study aimed to assess whether weight loss intervention improves hemoglobin A1c (HbA1c) in obese patients and to identify its associated factors.
A retrospective study was carried out on 318 patients with obesity class 1 or higher (body mass index [BMI] ≥ 30 kg/m) who underwent laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass at King Abdulaziz Medical City in Riyadh, Saudi Arabia, between January 1, 2001 and March 31, 2017. Preoperatively and 12 months postoperatively, characteristics of patients were collected. BMI reduction was calculated, based on which patients were divided into three groups (0-9, 10-14, and >14 kg/m).
The postoperative HbA1c was 5.83±0.9, while the baseline level was 6.74±2.1 (=0.001). Fifty-eight of the 318 patients had diabetes. We observed significantly higher HbA1c in diabetic than in non-diabetic patients preoperatively, whereas an insignificantly different HbA1c was observed postoperatively. Among those who had minimal reduction in BMI (0-9 kg/m), we observed significantly higher HbA1c in diabetic than in non-diabetic patients, whereas among those who had large reduction in BMI (10-14 kg/m) and (>14 kg/m), we observed insignificant differences in HbA1c in diabetic than in non-diabetic patients.
Being a diabetic patient was related to a significant reduction in HbA1c levels postoperatively. The study suggests that the reduction in HbA1c levels could be modified by BMI, wherein greater reduction in BMI leads to greater reduction in HbA1c levels.
尽管沙特阿拉伯外科减肥手术的频率有所增加，但描述沙特阿拉伯肥胖症手术临床结果的文献有限。本研究旨在评估减肥干预是否能改善肥胖患者的糖化血红蛋白（HbA1c）水平，并确定其相关因素。
对2001年1月1日至2017年3月31日期间在沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城接受腹腔镜袖状胃切除术或 Roux-en-Y 胃旁路术的318例1级或更高肥胖等级（体重指数[BMI]≥30 kg/m²）患者进行了一项回顾性研究。收集患者术前和术后12个月的特征。计算BMI降低值，并据此将患者分为三组（0 - 9、10 - 14和>14 kg/m²）。
术后HbA1c为5.83±0.9，而基线水平为6.74±2.1（P = 0.001）。318例患者中有58例患有糖尿病。术前，我们观察到糖尿病患者的HbA1c显著高于非糖尿病患者，而术后观察到的HbA1c差异不显著。在BMI降低最小的患者（0 - 9 kg/m²）中，我们观察到糖尿病患者的HbA1c显著高于非糖尿病患者，而在BMI降低较大的患者（10 - 14 kg/m²）和（>14 kg/m²）中，我们观察到糖尿病患者与非糖尿病患者的HbA1c差异不显著。
糖尿病患者术后HbA1c水平显著降低。该研究表明，HbA1c水平的降低可能受BMI影响，其中BMI降低幅度越大，HbA1c水平降低幅度越大。
