可见光促进的α-炔基苄基叠氮化物/炔丙基芳基叠氮化物的硒化/环化反应：硒代取代异喹啉和喹啉的合成
Visible-Light-Promoted Selenylation/Cyclization of -Alkynyl Benzylazides/-Propargyl Arylazides: Synthesis of Seleno-Substituted Isoquinolines and Quinolines.
作者信息
Gong Xi-Rui, Sun Shuang-Shuang, Ren Mei-Lin, Wu Qiao-Yan, Chen Yan-Yan, Xu Yan-Li
机构信息
Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, Key Laboratory of Medical Biotechnology and Translational Medicine, School of Pharmacy, Guilin Medical University, Guilin 541199, Guangxi, China.
出版信息
J Org Chem. 2024 Mar 15;89(6):4176-4184. doi: 10.1021/acs.joc.4c00247. Epub 2024 Mar 4.
A simple and efficient visible-light-promoted selenylation/cyclization of -alkynyl benzylazides/-propargyl arylazides have been realized for the practical synthesis of seleno-substituted isoquinolines and quinolines. This strategy provides the synthesis of valuable seleno-substituted isoquinoline and quinoline derivatives via the construction of one C(sp2)-Se bond and one C-N bond within one process.
一种简单高效的可见光促进的炔基苄基叠氮化物/炔丙基芳基叠氮化物的硒化/环化反应已被实现，用于实际合成硒取代的异喹啉和喹啉。该策略通过在一个过程中构建一个C(sp2)-Se键和一个C-N键，实现了有价值的硒取代异喹啉和喹啉衍生物的合成。
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