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AgSCF/NaSO促进的邻炔丙基芳基叠氮化物/邻炔基苄基叠氮化物的三氟甲硫基化/环化反应：SCF取代的喹啉和异喹啉的合成

AgSCF/NaSO-Promoted Trifluoromethylthiolation/Cyclization of o-Propargyl Arylazides/ o-Alkynyl Benzylazides: Synthesis of SCF-Substituted Quinolines and Isoquinolines.

作者信息

Qiu Yi-Feng, Niu Yue-Jie, Wei Xi, Cao Bao-Qian, Wang Xi-Cun, Quan Zheng-Jun

机构信息

College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou , Gansu 730070 , People's Republic of China.

Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials , Lanzhou , Gansu 730070 , People's Republic of China.

出版信息

J Org Chem. 2019 Apr 5;84(7):4165-4178. doi: 10.1021/acs.joc.9b00181. Epub 2019 Mar 13.

DOI:10.1021/acs.joc.9b00181
PMID:30835121
Abstract

A AgSCF/NaSO-promoted trifluoromethylthiolation/cascade cyclization of o-propargyl arylazides (or o-alkynyl benzylazides) triggered by a carbon-carbon triple bond is reported. This strategy provides the synthesis of valuable SCF-substituted quinoline and isoquinoline systems via the construction of one C(sp)-SCF bond and one C-N bond within one process.

摘要

报道了一种由碳-碳三键引发的AgSCF/NaSO促进的邻炔基芳基叠氮化物（或邻炔基苄基叠氮化物）的三氟甲硫基化/串联环化反应。该策略通过在一个过程中构建一个C(sp)-SCF键和一个C-N键，实现了有价值的SCF取代喹啉和异喹啉体系的合成。

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