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Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine.

作者信息

Isiksacan Ziya, D'Alessandro Angelo, McKenna David H, Tessier Shannon N, Kucukal Erdem, Gokaltun A Aslihan, William Nishaka, Sandlin Rebecca D, Bischof John, Mohandas Narla, Busch Michael P, Elbuken Caglar, Gurkan Umut A, Toner Mehmet, Acker Jason P, Yarmush Martin L, Usta O Berk

机构信息

Department of Surgery, Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

Shriners Children's, Boston, MA 02114.

出版信息

Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2320521121. doi: 10.1073/pnas.2320521121. Epub 2024 Mar 4.

DOI:10.1073/pnas.2320521121
PMID:38437566
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10945785/
Abstract
摘要

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Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance.蛋白质稳态和代谢功能障碍是一部分因储存而衰老的红细胞的特征，这些红细胞会在输血后被清除。
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Supercooled storage of red blood cells slows down the metabolic storage lesion.红细胞的过冷储存可减缓代谢性储存损伤。
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本文引用的文献

1
Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion.用于定量评估红细胞单位质量以及定制用于输血的培养红细胞的可翻译工具。
Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2318762121. doi: 10.1073/pnas.2318762121. Epub 2024 Mar 4.
2
Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine.通过芯片实验室技术评估储存的红细胞，以实现精准输血医学。
Proc Natl Acad Sci U S A. 2023 Aug 8;120(32):e2115616120. doi: 10.1073/pnas.2115616120. Epub 2023 Jul 26.
3
Comparing two extracellular additives to facilitate extended storage of red blood cells in a supercooled state.比较两种细胞外添加剂以促进红细胞在过冷状态下的长期储存。
Front Physiol. 2023 Jun 1;14:1165330. doi: 10.3389/fphys.2023.1165330. eCollection 2023.
4
Erysense, a Lab-on-a-Chip-Based Point-of-Care Device to Evaluate Red Blood Cell Flow Properties With Multiple Clinical Applications.Erysense，一种基于芯片实验室的即时检测设备，用于评估红细胞流动特性并具有多种临床应用。
Front Physiol. 2022 Apr 27;13:884690. doi: 10.3389/fphys.2022.884690. eCollection 2022.
5
Rapid clearance of storage-induced microerythrocytes alters transfusion recovery.储存诱导的小红细胞快速清除改变了输血恢复。
Blood. 2021 Apr 29;137(17):2285-2298. doi: 10.1182/blood.2020008563.
6
Objective assessment of stored blood quality by deep learning.深度学习评估贮存血质量
Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21381-21390. doi: 10.1073/pnas.2001227117. Epub 2020 Aug 24.
7
Deformability based sorting of stored red blood cells reveals donor-dependent aging curves.基于变形性的储存红细胞分选揭示了供体依赖性的衰老曲线。
Lab Chip. 2020 Jan 21;20(2):226-235. doi: 10.1039/c9lc01058k. Epub 2019 Dec 4.
8
Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells.从人外周血单个核细胞大规模体外生产红细胞。
Blood Adv. 2019 Nov 12;3(21):3337-3350. doi: 10.1182/bloodadvances.2019000689.
9
Red blood cell storage lesion: causes and potential clinical consequences.红细胞储存损伤：原因及潜在临床后果。
Blood Transfus. 2019 Jan;17(1):27-52. doi: 10.2450/2019.0217-18.