高血压合并日常生活活动受限与心血管疾病风险。
Hypertension combined with limitations in activities of daily living and the risk for cardiovascular disease.
机构信息
Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, 1800 Lihu Road, Binhu District, 214122, Wuxi, Jiangsu Province, China.
Center of Clinical Laboratory, The Fifth People's Hospital of Wuxi, Affiliated Hospital of Jiangnan University, Jiangnan University , 214011, Wuxi, Jiangsu, China.
出版信息
BMC Geriatr. 2024 Mar 4;24(1):225. doi: 10.1186/s12877-024-04832-6.
OBJECTIVE
The aim of present study was to evaluate the combined effect of hypertension and activities of daily living (ADL)/instrumental activities of daily living (IADL) with the risk of CVD, stroke and cardiac events.
METHODS
A total of 14,083 participants aged 45 years or older from the China Health and Retirement longitudinal study were included in current study. Participants were divided into 4 groups according to hypertension and ADL/IADL status. Cox proportional hazards regression model was used to explore the associations between hypertension, ADL/IADL and new-onset CVD, stroke and cardiac events.
RESULTS
During the 7-year follow-up, a total of 2,324 respondents experienced CVD (including 783 stroke and 1,740 cardiac events). Individuals with limitations in ADL alone, or with hypertension alone, or with both limitations in ADL and hypertension were associated with increased risk of CVD, with the adjusted hazard ratios (95% confidence intervals) were 1.17(1.00-1.35), 1.36(1.24-1.49) and 1.44(1.23-1.68), respectively. Those with limitations in ADL and hypertension also had higher risk of stroke (hazard ratios = 1.64; 1.26-2.14) and cardiac events (hazard ratios = 1.37; 1.14-1.64). Similarly, individuals with both limitations in IADL and hypertension were associated with increased risk of CVD (hazard ratios = 1.34; 1.15-1.57), stroke (hazard ratios = 1.50; 1.17-1.95) and cardiac events (hazard ratios = 1.27; 1.06-1.53).
CONCLUSION
Hypertension and limitations in ADL/IADL jointly increased the risk of CVD, stroke and cardiac events.
目的
本研究旨在评估高血压与日常生活活动（ADL）/工具性日常生活活动（IADL）的联合作用与心血管疾病（CVD）、中风和心脏事件风险的关系。
方法
本研究共纳入了来自中国健康与退休纵向研究的 14083 名年龄在 45 岁及以上的参与者。根据高血压和 ADL/IADL 情况，将参与者分为 4 组。采用 Cox 比例风险回归模型探讨高血压、ADL/IADL 与新发 CVD、中风和心脏事件之间的关系。
结果
在 7 年的随访期间，共有 2324 名受访者发生 CVD（包括 783 例中风和 1740 例心脏事件）。仅存在 ADL 受限、仅存在高血压、同时存在 ADL 和高血压受限的个体与 CVD 风险增加相关，调整后的风险比（95%置信区间）分别为 1.17（1.00-1.35）、1.36（1.24-1.49）和 1.44（1.23-1.68）。同时存在 ADL 和高血压受限的个体也具有更高的中风（风险比=1.64；1.26-2.14）和心脏事件（风险比=1.37；1.14-1.64）风险。同样，同时存在 IADL 受限和高血压的个体与 CVD（风险比=1.34；1.15-1.57）、中风（风险比=1.50；1.17-1.95）和心脏事件（风险比=1.27；1.06-1.53）风险增加相关。
结论
高血压和 ADL/IADL 受限联合增加了 CVD、中风和心脏事件的风险。
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