The Affiliated Brain Hospital of Guangzhou Medical University, 36 Mingxin Road, Liwan District, 510370, Guangzhou, Guangdong , China.
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
BMC Psychiatry. 2024 Mar 4;24(1):177. doi: 10.1186/s12888-024-05625-2.
Healthy lifestyle is an important protective factor of developing cardiovascular disease in people with schizophrenia. However, little is known about the determinants of lifestyle and its contribution to metabolic syndrome. This study aimed to explore the influencing factors of health-promoting lifestyle (HPL) and its association with metabolic syndrome among people with schizophrenia.
A cross-sectional study was conducted in twenty-two primary health centers of Guangzhou, China between December 2022 and April 2023. A total of 538 patients with schizophrenia were recruited through convenience sampling. Self-administered scales, questionnaires, and clinical data were collected. Scales and questionnaires included social-demographic information, Health-Promoting Lifestyles Profile (HPLP-C), UCLA Loneliness Scale (ULS), and International Physical Activity Questionnaire-Short Form (IPAQ-SF). Cluster analyses were used to divide participants into two groups based on the distribution characteristics of HPLP-C scores. Logistic regression models were used to identify factors associated with HPL and the association between HPL and metabolic syndrome.
There were 271 participants in the high HPL group and 267 participants in the low HPL group. Logistic regression analysis revealed that loneliness posed a risk factor for high HPL, while high education and moderate-vigorous physical activity served as protective factors for high HPL. Low HPL was a risk factor for the prevalence of metabolic syndrome.
Promotion of high education literacy and a physically active lifestyle should be priority targets in the health management of schizophrenia. Primary healthcare providers can play a pivotal role in assisting patients to mitigate metabolic syndrome by reinforcing healthy lifestyle strategies.
健康的生活方式是精神分裂症患者发生心血管疾病的重要保护因素。然而，关于生活方式的决定因素及其对代谢综合征的影响知之甚少。本研究旨在探讨精神分裂症患者健康促进生活方式（HPL）的影响因素及其与代谢综合征的关系。
本研究采用横断面研究，于 2022 年 12 月至 2023 年 4 月在广州市 22 家基层医疗卫生机构进行。通过便利抽样共招募了 538 名精神分裂症患者。采用自填式量表、问卷和临床数据收集方法。量表和问卷包括社会人口学信息、健康促进生活方式量表（HPLP-C）、加州大学洛杉矶分校孤独量表（UCLA）和国际体力活动问卷-短表（IPAQ-SF）。聚类分析根据 HPLP-C 得分的分布特征将参与者分为两组。采用逻辑回归模型确定与 HPL 相关的因素以及 HPL 与代谢综合征之间的关系。
有 271 名参与者被归入高 HPL 组，267 名参与者被归入低 HPL 组。逻辑回归分析显示，孤独感是高 HPL 的危险因素，而高教育程度和中高强度体力活动是高 HPL 的保护因素。低 HPL 是代谢综合征患病率的危险因素。
促进高教育水平和积极的生活方式应成为精神分裂症健康管理的优先目标。基层医疗服务提供者可以通过加强健康生活方式策略，在协助患者减轻代谢综合征方面发挥关键作用。
