Topcu Atakan, Yasin Ayse Irem, Besiroglu Mehmet, Sucuoglu Isleyen Zehra, Alaca Topcu Zeynep, Simsek Melih, Turk Haci Mehmet, Seker Mesut, Soysal Pinar
Bezmialem Vakif University Hospital, İstanbul, Türkiye.
Istanbul Medeniyet University Göztepe Prof Dr Süleyman Yalçın City Hospital, İstanbul, Türkiye.
Front Med (Lausanne). 2024 Feb 19;11:1331246. doi: 10.3389/fmed.2024.1331246. eCollection 2024.
Geriatric syndromes may be more common in older cancer patients than in those without cancer. Geriatric syndromes can cause poor clinical outcomes. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is often used as a clinically reported functional status score in oncology practice.
Our study was designed as a cross-sectional study and included 218 older cancer patients. This study aimed to determine the prevalence and relationship of geriatric syndromes according to the ECOG-PS in older cancer patients.
The mean age of 218 participants was 73.0 ± 5.6 years, with 47.7% being women and 52.3% men in our study. ECOG-PS 0, 1, and 2 groups contained 51, 39, and 10% of the patients, respectively. The mean number of geriatric syndromes in the ECOG 0, 1, and 2 groups was 2.3 ± 2.2, 4.3 ± 2.4, and 5.7 ± 2.1, respectively ( < 0.001). After adjusting for age and sex, it was determined that dynapenia was 2.9 times, probable sarcopenia was 3.5 times, frailty was 4.2 times, depression was 2.6 times, malnutrition was 3.3 times, insomnia 2 was.2 times, falls was 2.5 times, and the risk of falling (TUG) was 2.4 times more likely in those with ECOG-PS 1 compared to those with ECOG-PS 0. In addition, it was found that dynapenia was 6 times, probable sarcopenia was 6.8 times, frailty was 10.8 times, depression was 3.3 times, malnutrition was 6.3 times, the risk of falling (Tinnetti Balance) was 28 times, and the risk of falling (TUG) was 13.6 times more likely in those with ECOG-PS 2 compared to those with ECOG-PS 0.
Our study found that the prevalence of geriatric syndromes increased as the ECOG-PS increased. Geriatric syndromes and their co-incidence were common in older cancer patients, even in normal performance status. Oncologists should incorporate geriatric syndromes into the decision-making process of cancer treatment to maximize the impact on clinical outcomes in older patients with cancer.
老年综合征在老年癌症患者中可能比非癌症患者更常见。老年综合征可导致不良的临床结局。东部肿瘤协作组体能状态（ECOG-PS）在肿瘤学实践中常被用作临床报告的功能状态评分。
我们的研究设计为横断面研究，纳入了218例老年癌症患者。本研究旨在根据ECOG-PS确定老年癌症患者中老年综合征的患病率及其关系。
218名参与者的平均年龄为73.0±5.6岁，其中女性占47.7%，男性占52.3%。ECOG-PS 0、1和2组分别包含51%、39%和10%的患者。ECOG 0、1和2组中老年综合征的平均数量分别为2.3±2.2、4.3±2.4和5.7±2.1（<0.001）。在调整年龄和性别后，确定与ECOG-PS 0组相比，ECOG-PS 1组患者的肌无力风险高2.9倍，可能的肌肉减少症风险高3.5倍，衰弱风险高4.2倍，抑郁风险高2.6倍，营养不良风险高3.3倍，失眠风险高2.2倍，跌倒风险高2.5倍，定时起立行走试验（TUG）评估的跌倒风险高2.4倍。此外，还发现与ECOG-PS 0组相比，ECOG-PS 2组患者的肌无力风险高6倍，可能的肌肉减少症风险高6.8倍，衰弱风险高10.8倍，抑郁风险高3.3倍，营养不良风险高6.3倍，Tinetti平衡量表评估的跌倒风险高28倍，TUG评估的跌倒风险高13.6倍。
我们的研究发现，随着ECOG-PS升高，老年综合征的患病率增加。老年综合征及其合并症在老年癌症患者中很常见，即使在体能状态正常的患者中也是如此。肿瘤学家应将老年综合征纳入癌症治疗的决策过程，以最大限度地影响老年癌症患者的临床结局。
