Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı (Vatan Street), 34093, Fatih, Istanbul, Turkey.
Aging Clin Exp Res. 2021 Sep;33(9):2599-2603. doi: 10.1007/s40520-020-01774-y. Epub 2021 Jan 28.
This study was aimed to compare early-stage Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), the two most common types of dementia in the elderly, in terms of the prevalence of geriatric syndromes. Patients with early-stage dementia with DLB and AD were included, and were questioned in terms of geriatric syndromes including polypharmacy, malnutrition, frailty, sarcopenia, dynapenia, orthostatic hypotension (OH), urinary and fecal incontinence, falls, fear of falling (FoF), depression, insomnia, excessive daytime sleepiness, pressure ulcers. Of the 82 patients, 31 had DLB and 51 had AD. The mean age was 80.99 ± 7.01, and 69.5% was female. The presence of OH, FoF, depression, and insomnia were more common in the DLB than AD (p < 0.05). 90.3% of patients with DLB and 54.9% of patients with AD had ≥ 3 geriatric syndromes simultaneously. The presence and co-incidence of geriatric syndromes is common in patients with even early-stage DLB and AD.
本研究旨在比较早发性老年痴呆症 (AD) 和路易体痴呆症 (DLB) 这两种老年人最常见的痴呆症类型，在老年综合病症的流行率方面。纳入了早发性痴呆症合并 DLB 和 AD 的患者，并询问了包括多药治疗、营养不良、虚弱、肌肉减少症、无力、体位性低血压 (OH)、尿失禁和大便失禁、跌倒、跌倒恐惧 (FoF)、抑郁、失眠、白天过度嗜睡、压疮等老年综合病症。82 名患者中，31 名患有 DLB，51 名患有 AD。平均年龄为 80.99±7.01，69.5%为女性。DLB 比 AD 更常见 OH、FoF、抑郁和失眠（p<0.05）。90.3%的 DLB 患者和 54.9%的 AD 患者同时存在≥3 种老年综合病症。即使是早发性 DLB 和 AD 患者，老年综合病症的存在和同时发生也很常见。
