Song Honghu, Liu Jiancheng, Wang Linjie, Hu Xiaomin, Li Jiayu, Zhu Li, Pang Rizhao, Zhang Anren
School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Rehabilitation Medicine, General Hospital of Western Theater Command, Chengdu, China.
Front Neurosci. 2024 Feb 19;18:1348844. doi: 10.3389/fnins.2024.1348844. eCollection 2024.
Alzheimer's disease (AD) is a prevalent neurodegenerative disease that has become one of the main factors affecting human health. It has serious impacts on individuals, families, and society. With the development of population aging, the incidence of AD will further increase worldwide. Emerging evidence suggests that many physiological metabolic processes, such as lipid metabolism, are implicated in the pathogenesis of AD. Bile acids, as the main undertakers of lipid metabolism, play an important role in the occurrence and development of Alzheimer's disease. Tauroursodeoxycholic acid, an endogenous bile acid, has been proven to possess therapeutic effects in different neurodegenerative diseases, including Alzheimer's disease. This review tries to find the relationship between bile acid metabolism and AD, as well as explore the therapeutic potential of bile acid taurocursodeoxycholic acid for this disease. The potential mechanisms of taurocursodeoxycholic acid may include reducing the deposition of Amyloid-β protein, regulating apoptotic pathways, preventing tau hyperphosphorylation and aggregation, protecting neuronal synapses, exhibiting anti-inflammatory properties, and improving metabolic disorders. The objective of this study is to shed light on the use of tauroursodeoxycholic acid preparations in the prevention and treatment of AD, with the aim of identifying effective treatment targets and clarifying various treatment mechanisms involved in this disease.
阿尔茨海默病（AD）是一种常见的神经退行性疾病，已成为影响人类健康的主要因素之一。它对个人、家庭和社会都有严重影响。随着人口老龄化的发展，AD在全球的发病率将进一步上升。新出现的证据表明，许多生理代谢过程，如脂质代谢，都与AD的发病机制有关。胆汁酸作为脂质代谢的主要承担者，在阿尔茨海默病的发生和发展中起着重要作用。牛磺熊去氧胆酸，一种内源性胆汁酸，已被证明在包括阿尔茨海默病在内的不同神经退行性疾病中具有治疗作用。本综述试图找出胆汁酸代谢与AD之间的关系，并探讨胆汁酸牛磺熊去氧胆酸对该疾病的治疗潜力。牛磺熊去氧胆酸的潜在机制可能包括减少淀粉样β蛋白的沉积、调节凋亡途径、防止tau蛋白过度磷酸化和聚集、保护神经元突触、表现出抗炎特性以及改善代谢紊乱。本研究的目的是阐明牛磺熊去氧胆酸制剂在AD预防和治疗中的应用，旨在确定有效的治疗靶点并阐明该疾病涉及的各种治疗机制。
