Galib Rubina, Gupta Nainsi, Rahman Abdur, Aftab Mohd, Qadri Shagufta, Alam Kiran
Department of Otorhinolaryngology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002 India.
Department of Pathology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh 202002 India.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1138-1142. doi: 10.1007/s12070-023-04178-2. Epub 2023 Sep 7.
Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare, benign, reactive vaso-proliferative condition in the dermal and subcutaneous tissues of the head and neck. A 28-year-old female presented with slow-growing painless swelling behind her left ear. FNAC revealed benign soft tissue neoplasm and histopathological examination after surgical excision revealed angiolymphoid hyperplasia with eosinophilia. ALHE origin has been variously attributed to prior trauma, hyperestrogenemia, infectious agents, atopy, reactive hyperplasia, and benign neoplasia. Retroauricular ALHE has been rarely reported. However, on the basis of our case report, it should be a viable differential diagnosis when large subcutaneous tumors of the head and neck are encountered. When big subcutaneous tumors of the head and neck are present, especially in females, a valid differential diagnosis for angiolymphoid hyperplasia with eosinophilia, a rare condition marked by dermal or subcutaneous endothelial cell proliferation, should also be considered.
嗜酸性粒细胞增多性血管淋巴样增生(ALHE)是一种罕见的、良性的、发生于头颈部皮肤和皮下组织的反应性血管增生性疾病。一名28岁女性患者,左耳后出现生长缓慢的无痛性肿块。细针穿刺活检显示为良性软组织肿瘤,手术切除后的组织病理学检查显示为嗜酸性粒细胞增多性血管淋巴样增生。ALHE的起源有多种说法,包括既往创伤、高雌激素血症、感染因子、特应性、反应性增生和良性肿瘤形成。耳后ALHE鲜有报道。然而,根据我们的病例报告,当遇到头颈部的大型皮下肿瘤时,它应作为一个可行的鉴别诊断。当头颈部出现大型皮下肿瘤时,尤其是在女性患者中,对于嗜酸性粒细胞增多性血管淋巴样增生(一种以皮肤或皮下内皮细胞增生为特征的罕见疾病)也应考虑进行有效的鉴别诊断。