Khanzadeh Monireh, Foroughi Nematollahi Sima, Shavakhi Mitra, Ghaedi Arshin, Mallahi Amirhossein, Bazrgar Aida, Khanzadeh Shokoufeh
Geriatric and Gerontology Department, Medical School, Tehran University of Medical and Health Sciences, Tehran, Iran.
Kerman University of Medical Sciences, Kerman, Iran.
Indian J Otolaryngol Head Neck Surg. 2024 Feb;76(1):1389-1397. doi: 10.1007/s12070-023-04148-8. Epub 2023 Sep 1.
One of the crucial triggers of allergic diseases is an inflammatory reaction and neutrophil to lymphocyte ratio (NLR) is one of the systemic inflammation biomarkers. Our review aimed to evaluate role of NLR in predicting severity and comorbidities of allergic rhinitis (AR). We systematically searched Scopus, Web of Science, and PubMed to find relevant studies. Standardized mean difference (SMD) with a 95% confidence interval (CI) was reported. Due to the high levels of heterogeneity, the random-effects model was used to generate pooled effects. Eleven articles were included in the systematic review, among which ten were included in meta-analysis including 1122 healthy controls and 1423 patients with AR. We found that patients with AR had a significantly higher level of NLR than healthy controls (SMD = 0.19, 95%CI = 0.03-0.36, = 0.03). In addition, patients with moderate to severe AR had significantly higher levels of NLR compared to those with mild AR (SMD = 0.41, 95%CI = 0.20-0.63, < 0.001). Interestingly, it was found that NLR could associate with some comorbidities of AR, like asthma. Our results confirmed that NLR could assist clinicians in predicting the severity and comorbidities of AR.
The online version contains supplementary material available at 10.1007/s12070-023-04148-8.
过敏性疾病的关键触发因素之一是炎症反应，中性粒细胞与淋巴细胞比值（NLR）是全身炎症生物标志物之一。我们的综述旨在评估NLR在预测过敏性鼻炎（AR）严重程度和合并症中的作用。我们系统检索了Scopus、科学网和PubMed以查找相关研究。报告了具有95%置信区间（CI）的标准化均数差（SMD）。由于异质性水平较高，采用随机效应模型生成合并效应。系统评价纳入了11篇文章，其中10篇纳入荟萃分析，包括1122名健康对照者和1423例AR患者。我们发现，AR患者的NLR水平显著高于健康对照者（SMD = 0.19，95%CI = 0.03 - 0.36，P = 0.03）。此外，中重度AR患者的NLR水平显著高于轻度AR患者（SMD = 0.41，95%CI = 0.20 - 0.63，P < 0.001）。有趣的是，发现NLR可能与AR的一些合并症相关，如哮喘。我们的结果证实，NLR可协助临床医生预测AR的严重程度和合并症。
在线版本包含可在10.1007/s12070-023-04148-8获取的补充材料。
