Department of Medical Laboratory Sciences, School of Allied Medical Sciences, University of Medical Sciences, Arak, Iran.
School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Eur J Med Res. 2024 Nov 27;29(1):562. doi: 10.1186/s40001-024-02155-1.
We aimed to determine the association of neutrophil-to-lymphocyte ratio (NLR) with non-arteritic anterior ischemic optic neuropathy (NAION).
We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Scopus and Web of Science were searched from the establishment of the database to May 5, 2022 to find the relevant studies. The quality of the included literature was evaluated with the Newcastle-Ottawa scale (NOS). The results are reflected in the form of standard mean difference (SMD) and 95% confidence interval (CI).
Finally, six articles were included in our study. Compared with healthy controls, patients' NLR levels were significantly higher (SMD = 0.47; CI 95% = 0.30-0.65, p<0.001). The included studies were not statistically heterogeneous (I = 0.0%, p = 0.60); thus, the analysis used the fixed-effect model. The pooled sensitivity of NLR was 0.69 (95% CI 0.60-0.67), and the pooled specificity was 0.59 (95% CI 0.50-0.67). The pooled positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio (DOR) of NLR were 1.71(95%CI 1.48-1.98), 0.50 (95%CI 0.41-0.62), and 3.38 (95%CI 2.57-4.44), respectively.
Our findings suggest NLR to be a potential marker of NAION, while also implicating a role for inflammation in underlying pathophysiology.
本研究旨在探讨中性粒细胞与淋巴细胞比值（NLR）与非动脉炎性前部缺血性视神经病变（NAION）之间的相关性。
我们按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行了系统综述和荟萃分析。从数据库建立到 2022 年 5 月 5 日，我们在 PubMed、Scopus 和 Web of Science 上搜索了相关研究。使用纽卡斯尔-渥太华量表（NOS）评估纳入文献的质量。结果以标准化均数差（SMD）和 95%置信区间（CI）表示。
最终纳入了 6 项研究。与健康对照组相比，患者的 NLR 水平显著升高（SMD = 0.47；95%CI 95% = 0.30-0.65，p<0.001）。纳入的研究无统计学异质性（I = 0.0%，p = 0.60）；因此，分析采用固定效应模型。NLR 的合并灵敏度为 0.69（95%CI 0.60-0.67），特异度为 0.59（95%CI 0.50-0.67）。NLR 的合并阳性似然比、阴性似然比、诊断比值比（DOR）分别为 1.71（95%CI 1.48-1.98）、0.50（95%CI 0.41-0.62）和 3.38（95%CI 2.57-4.44）。
我们的研究结果表明 NLR 可能是 NAION 的潜在标志物，同时也提示炎症在其发病机制中发挥作用。
