Mandal Arnab, Khan Abu Taleb
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.
Org Biomol Chem. 2024 Mar 20;22(12):2339-2358. doi: 10.1039/d4ob00034j.
The synthesis of quinoline derivatives through multicomponent reactions (MCRs) has emerged as an efficient and versatile strategy in organic synthesis. MCRs offer the advantage of constructing complex molecular architectures in a single step, utilising multiple starting materials in a convergent manner. This review provides an overview of recent advancements in the field of quinoline synthesis MCRs. Various MCRs, such as the Povarov reaction, the Gewald reaction, and the Ugi reaction have been successfully employed for the synthesis of diverse quinoline scaffolds. These methodologies not only showcase high atom economy but also allow the incorporation of structural diversity into the final products. The versatility of MCRs enables the introduction of functional groups and substitution patterns tailored to specific applications. This review highlights the significance of quinoline derivatives in medicinal chemistry, materials science, and other interdisciplinary areas. The continuous innovation and development of novel MCR-based approaches for quinoline synthesis hold great promise for the rapid and efficient generation of valuable compounds with a wide range of biological and physicochemical properties.
通过多组分反应（MCRs）合成喹啉衍生物已成为有机合成中一种高效且通用的策略。MCRs具有一步构建复杂分子结构的优势，以汇聚的方式利用多种起始原料。本综述概述了喹啉合成MCRs领域的最新进展。各种MCRs，如Povarov反应、Gewald反应和Ugi反应，已成功用于合成各种喹啉骨架。这些方法不仅展示了高原子经济性，还能将结构多样性引入最终产物中。MCRs的通用性使得能够引入适合特定应用的官能团和取代模式。本综述强调了喹啉衍生物在药物化学、材料科学和其他跨学科领域中的重要性。基于新型MCRs的喹啉合成方法的不断创新和发展，为快速高效地生成具有广泛生物和物理化学性质的有价值化合物带来了巨大希望。
