• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脊柱后凸侧弯并发哮喘伴固定性气道阻塞。

Kyphoscoliosis complicating asthma with fixed airway obstruction.

作者信息

Bonello Sarah, Farrugia Yanika, Mallia Theresa, Maniscalco Nicoletta, Balzan Martin

机构信息

Mater Dei Hospital, Malta.

出版信息

Multidiscip Respir Med. 2024 Jan 29;19(1):937. doi: 10.5826/mrm.2024.937. eCollection 2024 Feb 6.

DOI:10.5826/mrm.2024.937
PMID:38444560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10865733/
Abstract

INTRODUCTION

Kyphoscoliosis is present in up to 2% of the juvenile population and can have deleterious effects on respiratory mechanics, leading to chronic respiratory failure later on in adult life.

CASE PRESENTATION

Hereby we describe a 53-year-old patient with severe uncontrolled asthma who presented with chronic hypercapnic respiratory failure. During her medical workup, she was noted to have several comorbidities leading to her respiratory failure. The patient had radiological evidence of bronchiectasis with recurrent episodes of infection, and a severe deformity of the spine due to Kyphoscoliosis. Probably the kyphotic component of this deformity had worsened due to a long history of oral steroid use leading to severe osteoporosis and consequent vertebral compression fractures reaching a Cobb angle of 73 degrees. This was probably caused by the patient's non-compliance with inhaler therapy and an excessive reliance on oral steroid use. Her respiratory failure was treated with domiciliary noninvasive positive pressure ventilation and 24-hour oxygen therapy and her symptoms improved.

CONCLUSION

A multidisciplinary approach across different specialities is necessary when managing such a patient with kyphoscoliosis, bronchiectasis, asthma with airflow limitation with respiratory failure.

摘要

引言

脊柱后凸侧弯在高达2%的青少年人群中存在，并且会对呼吸力学产生有害影响，导致成年后期出现慢性呼吸衰竭。

病例报告

在此我们描述一名53岁患有严重未控制哮喘的患者，该患者出现慢性高碳酸血症性呼吸衰竭。在其医学检查过程中，发现她有多种导致呼吸衰竭的合并症。该患者有支气管扩张伴反复感染发作的影像学证据，以及因脊柱后凸侧弯导致的严重脊柱畸形。可能由于长期口服类固醇导致严重骨质疏松及随后的椎体压缩骨折，该畸形的后凸成分加重，Cobb角达到73度。这可能是由于患者不依从吸入器治疗以及过度依赖口服类固醇使用所致。她的呼吸衰竭采用家庭无创正压通气和24小时氧疗进行治疗，症状得到改善。

结论

在管理患有脊柱后凸侧弯、支气管扩张、气流受限伴呼吸衰竭的哮喘患者时，需要不同专科的多学科方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/87eec89847a6/mrm-19-1-937-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/1a118bd67af7/mrm-19-1-937-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/0b10c6789033/mrm-19-1-937-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/3ac4182f827f/mrm-19-1-937-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/a9b8709874f3/mrm-19-1-937-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/e58281757843/mrm-19-1-937-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/87eec89847a6/mrm-19-1-937-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/1a118bd67af7/mrm-19-1-937-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/0b10c6789033/mrm-19-1-937-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/3ac4182f827f/mrm-19-1-937-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/a9b8709874f3/mrm-19-1-937-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/e58281757843/mrm-19-1-937-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b22/10865733/87eec89847a6/mrm-19-1-937-g006.jpg

相似文献

1
Kyphoscoliosis complicating asthma with fixed airway obstruction.脊柱后凸侧弯并发哮喘伴固定性气道阻塞。
Multidiscip Respir Med. 2024 Jan 29;19(1):937. doi: 10.5826/mrm.2024.937. eCollection 2024 Feb 6.
2
[3D printing technology assisted the preoperative planning and application value in adult kyphoscoliosis deformity].[3D打印技术在成人脊柱侧凸畸形术前规划中的辅助作用及应用价值]
Zhongguo Gu Shang. 2020 Feb 25;33(2):99-105. doi: 10.12200/j.issn.1003-0034.2020.02.002.
3
[Standard technical specifications for methacholine chloride (Methacholine) bronchial challenge test (2023)].[氯化乙酰甲胆碱支气管激发试验标准技术规范（2023年）]
Zhonghua Jie He He Hu Xi Za Zhi. 2024 Feb 12;47(2):101-119. doi: 10.3760/cma.j.cn112147-20231019-00247.
4
Asthma is not a common cause of severe chronic respiratory failure in non-smokers: ALOT study.哮喘并非非吸烟者严重慢性呼吸衰竭的常见病因：ALOT研究。
Monaldi Arch Chest Dis. 2005 Jun;63(2):84-7. doi: 10.4081/monaldi.2005.643.
5
Posterior-approach single-level apical spinal osteotomy in pediatric patients for severe rigid kyphoscoliosis: long-term clinical and radiological outcomes.小儿严重僵硬型脊柱侧凸患者后路单节段顶椎截骨术：长期临床和影像学结果
J Neurosurg Pediatr. 2018 Jun;21(6):606-614. doi: 10.3171/2017.12.PEDS17404. Epub 2018 Mar 30.
6
[A multi-centre randomized controlled trial of domiciliary non-invasive ventilation vs long-term oxygen therapy in survivors of acute hypercapnic respiratory failure due to COPD. Non-invasive ventilation in obstructive lung disease (NIVOLD) study].[一项关于慢性阻塞性肺疾病所致急性高碳酸血症呼吸衰竭幸存者家庭无创通气与长期氧疗的多中心随机对照试验。阻塞性肺疾病无创通气（NIVOLD）研究]
Rev Mal Respir. 2012 Nov;29(9):1141-8. doi: 10.1016/j.rmr.2012.09.006. Epub 2012 Oct 16.
7
Hypercapnic respiratory failure during pregnancy due to polymyositis-related respiratory muscle weakness: a case report.妊娠期间因多发性肌炎相关呼吸肌无力导致的高碳酸血症性呼吸衰竭：一例报告
J Med Case Rep. 2017 Jul 26;11(1):203. doi: 10.1186/s13256-017-1368-2.
8
Balloon kyphoplasty: an evidence-based analysis.球囊椎体后凸成形术：一项基于证据的分析。
Ont Health Technol Assess Ser. 2004;4(12):1-45. Epub 2004 Dec 1.
9
Hypercapnic cerebral edema presenting in a woman with asthma: a case report.一名哮喘女性患者出现高碳酸血症性脑水肿：病例报告
J Med Case Rep. 2011 May 20;5:192. doi: 10.1186/1752-1947-5-192.
10
Morgagni hernia with respiratory failure aggravated by noninvasive positive pressure ventilation: a case report and overview of the literature.伴有无创正压通气加重呼吸衰竭的莫尔加尼疝：一例病例报告及文献综述
Respir Investig. 2014 May;52(3):203-8. doi: 10.1016/j.resinv.2013.11.001. Epub 2014 Jan 18.

本文引用的文献

1
Moiré topography as a screening and diagnostic tool-A systematic review.Moiré 地形学作为一种筛选和诊断工具——系统评价。
PLoS One. 2021 Dec 2;16(12):e0260858. doi: 10.1371/journal.pone.0260858. eCollection 2021.
2
Long-Term Survival on Noninvasive Ventilation in Adults With Thoracic Scoliosis.成人胸腰椎侧凸患者无创通气的长期生存。
Respir Care. 2021 Jun;66(6):972-975. doi: 10.4187/respcare.07848. Epub 2021 Mar 9.
3
Effects of exercise programs on kyphosis and lordosis angle: A systematic review and meta-analysis.运动方案对后凸和前凸角度的影响：系统评价和荟萃分析。
PLoS One. 2019 Apr 29;14(4):e0216180. doi: 10.1371/journal.pone.0216180. eCollection 2019.
4
Scoliosis conservative treatment: A review of literature.脊柱侧弯的保守治疗：文献综述
J Craniovertebr Junction Spine. 2018 Jan-Mar;9(1):3-8. doi: 10.4103/jcvjs.JCVJS_39_17.
5
Screening for Adolescent Idiopathic Scoliosis: US Preventive Services Task Force Recommendation Statement.青少年特发性脊柱侧凸筛查：美国预防服务工作组推荐声明。
JAMA. 2018 Jan 9;319(2):165-172. doi: 10.1001/jama.2017.19342.
6
European Respiratory Society guidelines for the management of adult bronchiectasis.欧洲呼吸学会成人支气管扩张症管理指南。
Eur Respir J. 2017 Sep 9;50(3). doi: 10.1183/13993003.00629-2017. Print 2017 Sep.
7
Clinical characteristics of patients with chronic obstructive pulmonary disease with comorbid bronchiectasis: a systemic review and meta-analysis.慢性阻塞性肺疾病合并支气管扩张患者的临床特征：一项系统评价和荟萃分析。
Int J Chron Obstruct Pulmon Dis. 2015 Jul 28;10:1465-75. doi: 10.2147/COPD.S83910. eCollection 2015.
8
Pulmonary rehabilitation improves exercise capacity in subjects with kyphoscoliosis and severe respiratory impairment.肺康复可提高脊柱后凸侧弯和严重呼吸功能障碍患者的运动能力。
Respir Care. 2015 Jan;60(1):96-101. doi: 10.4187/respcare.03095. Epub 2014 Sep 16.
9
Kyphosis and review of the literature.脊柱后凸及文献综述
Turk Neurosurg. 2014;24(4):455-65. doi: 10.5137/1019-5149.JTN.8940-13.0.
10
Clinical practice. Idiopathic scoliosis in adolescents.临床实践。青少年特发性脊柱侧凸
N Engl J Med. 2013 Feb 28;368(9):834-41. doi: 10.1056/NEJMcp1209063.