The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.
Expert Rev Clin Immunol. 2024 Jul;20(7):793-801. doi: 10.1080/1744666X.2024.2324005. Epub 2024 Mar 11.
This article aims to evaluate the magnitude of adverse pregnancy outcomes (APOs) risks associated with different antiphospholipid antibody (aPL) profiles in women with systemic lupus erythematosus (SLE).
Multiple databases were investigated to identify articles that explored the relationship between aPLs and APOs in SLE patients. A random effects model was used for calculating pooled odds ratios (OR). Stata version 15.0 was utilized to conduct the meta-analysis.
There were 5234 patients involved in 30 studies. Overall aPL was linked to an increased incidence of any kind of APOs, fetal loss, and preterm birth. Any kind of APOs and preterm delivery were more common in patients with lupus anticoagulant (LA) positive. Anticardiolipin antibody (aCL) was associated with an increased risk of any kind of APOs and fetal loss. The association between aCL-IgM and fetal loss was also significant. Patients with anti-beta2-glycoprotein1 antibody (antiβ2GP1) positivity had an increased risk of fetal loss.
Both LA and aCL were risk factors of APOs in patients with SLE. Not only ACL, particularly aCL-IgM, but antiβ2GP1 were associated with an increased risk of fetal loss, while LA appeared to indicate the risk of preterm birth.PROSPERO (CRD42023388122).
本文旨在评估系统性红斑狼疮（SLE）患者不同抗磷脂抗体（aPL）谱与不良妊娠结局（APOs）风险的关联程度。
检索多个数据库，以确定探讨 SLE 患者 aPL 与 APOs 之间关系的文章。采用随机效应模型计算汇总优势比（OR）。使用 Stata 版本 15.0 进行荟萃分析。
共有 5234 名患者纳入 30 项研究。总体而言，aPL 与任何类型的 APOs、胎儿丢失和早产的发生率增加有关。LA 阳性患者更易发生任何类型的 APOs 和早产。抗心磷脂抗体（aCL）与任何类型的 APOs 和胎儿丢失风险增加相关。aCL-IgM 与胎儿丢失之间的关联也具有统计学意义。抗β2-糖蛋白 1 抗体（antiβ2GP1）阳性患者的胎儿丢失风险增加。
LA 和 aCL 均是 SLE 患者 APOs 的危险因素。不仅 ACL，特别是 aCL-IgM，与胎儿丢失风险增加相关，而 LA 似乎提示早产风险增加。PROSPERO（CRD42023388122）。
