Centre for Advanced Biotherapeutics and Regenerative Medicine, FAHS, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, India.
Research and Collaboration, Anka Analytica, Melbourne, Australia.
Mol Biol Rep. 2024 Mar 6;51(1):393. doi: 10.1007/s11033-024-09302-1.
Microvesicles (MVs) serve as biomarkers and transmitters for cell communication and also act as essential contributors to diseases. Platelets release microvesicles when activated voluntarily, making them a significant source. Platelet-derived microvesicles possess a range of characteristics similar to their parent cells and were shown to exert regulatory impacts on vascular and immunological cells. MVs can alter the activity of recipient cells by transferring their internal components. Furthermore, it has been identified that microvesicles derived from platelets possess the ability to exert immunomodulatory effects on different kinds of cells. Recent research has shown that microvesicles have a bidirectional influence of harming and preventing the receptor cells. Nevertheless, the specific characteristics of the active molecules responsible for this phenomenon are still unknown. The primary focus of this review was to explore the mechanism of vascular tissue regeneration and the specific molecules that play a role in mediating various biological effects throughout this process. These molecules exert their effects by influencing autophagy, apoptosis, and inflammatory pathways.
微囊泡 (MVs) 作为细胞通讯的生物标志物和传递者，也是疾病的重要贡献者。血小板在被激活时会自主释放微囊泡，使其成为重要的来源。血小板衍生的微囊泡具有与母细胞相似的一系列特征，并被证明对血管和免疫细胞具有调节作用。MVs 可以通过转移其内部成分来改变受体细胞的活性。此外，已经发现血小板衍生的微囊泡具有对不同类型的细胞发挥免疫调节作用的能力。最近的研究表明，微囊泡对受体细胞具有双向的伤害和保护作用。然而，导致这种现象的活性分子的具体特征尚不清楚。本综述的主要重点是探讨血管组织再生的机制，以及在这个过程中调节各种生物学效应的特定分子。这些分子通过影响自噬、细胞凋亡和炎症途径发挥作用。
