Department of Emergency Medicine, The Second Xiangya Hospital of Central-South University, Emergency and Difficult Diseases Institute of Central South University, Changsha, Hunan, China.
Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Heart Lung. 2024 May-Jun;65:84-92. doi: 10.1016/j.hrtlng.2024.02.005. Epub 2024 Mar 5.
The occurrence of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Oxidation Balance Score (OBS) can evaluate the oxidation and antioxidant status of the body. However, we found no studies that examined the association between the two.
To assess the association between OBS and COPD prevalence, and to explore dietary and lifestyle patterns aimed at preventing and delay COPD in adults.
We included 13,909 participants using data from the NHANES. Weighted logistic regression model and weighted restricted cubic spline curve were used to explore the relationship between OBS and COPD. Subgroup analysis and sensitivity analysis were used to determine the stability of results. Mediation analysis was employed to assess the effect of inflammatory factors.
In logistic regression model, compared with the lowest quartile of OBS, the highest quartile of OBS, diet OBS, lifestyle OBS and COPD had odd ratios OR(95%CI)=0.67 (0.51, 0.89), OR (95% CI) = 0.71 (0.55, 0.93), and OR (95% CI) = 0.39 (0.26, 0.58) respectively. The restricted cubic spline curve reveals that OBS and dietary OBS exhibit an L-shaped curve in relation to COPD prevalence, while lifestyle OBS shows a negative correlation curve with COPD prevalence. Subgroup analysis and sensitivity analysis proved the robustness of the association. Mediation analysis demonstrated that inflammatory factors mediate the association of OBS on the prevalence of COPD.
The increase of OBS, dietary OBS, and lifestyle OBS was associated with a decrease in the prevalence of COPD, but excessive OBS and dietary OBS were associated with an inapparent decrease or even increased risk of COPD.
慢性阻塞性肺疾病（COPD）的发生与氧化应激有关。氧化平衡评分（OBS）可以评估机体的氧化和抗氧化状态。然而，我们尚未发现研究探讨两者之间的关联。
评估 OBS 与 COPD 患病率之间的关联，并探讨旨在预防和延缓成年人 COPD 发生的饮食和生活方式模式。
我们纳入了来自 NHANES 的 13909 名参与者的数据。使用加权逻辑回归模型和加权限制立方样条曲线来探讨 OBS 与 COPD 之间的关系。进行亚组分析和敏感性分析以确定结果的稳定性。采用中介分析评估炎症因子的作用。
在逻辑回归模型中，与 OBS 最低四分位数相比，OBS 最高四分位数、饮食 OBS、生活方式 OBS 与 COPD 的比值比（OR）（95%CI）分别为 0.67（0.51，0.89）、0.71（0.55，0.93）和 0.39（0.26，0.58）。限制立方样条曲线显示，OBS 和饮食 OBS 与 COPD 患病率呈 L 形曲线关系，而生活方式 OBS 与 COPD 患病率呈负相关曲线关系。亚组分析和敏感性分析证明了这种关联的稳健性。中介分析表明，炎症因子介导了 OBS 与 COPD 患病率之间的关联。
OBS、饮食 OBS 和生活方式 OBS 的增加与 COPD 患病率的降低相关，但 OBS 和饮食 OBS 的过度增加与 COPD 患病率的降低不明显甚至增加相关。
