Terzi Merve, Bulut İsmet, Yakut Tuğçe, Güneş Fatma Esra
, Department of Nutrition and Dietetics, Istanbul Yeni Yüzyıl University, Istanbul, Turkey.
Department of Nutrition and Dietetics, Graduate School of Health Sciences, Istanbul Medipol University, Istanbul, Turkey.
BMC Pulm Med. 2025 May 6;25(1):216. doi: 10.1186/s12890-025-03682-1.
This study aimed to assess the nutritional status of individuals with severe asthma and to determine how dietary antioxidant (AO) intake influences the disease prognosis and plasma total antioxidant status (TAS).
The study included 44 patients with severe asthma and 45 healthy participants. Anthropometric measurements, asthma control levels, scores from a validated antioxidant food consumption frequency questionnaire, 3-day food records, and demographic information were gathered from each participant. Blood samples obtained after overnight fasting were analyzed for plasma TAS and total oxidant status (TOS).
The mean antioxidant intake measured by the FFQ and food records, as well as plasma TAS levels, were significantly lower in the asthma group compared to the control group (p < 0.05). In the asthma group, negative correlations were found between the duration of asthma and both plasma TAS and antioxidant intake from the FFQ and food records, indicating that longer asthma duration was associated with lower antioxidant status (p < 0.05). Additionally, a positive correlation was observed between the asthma control level and the antioxidant intake from the FFQ in the case group, suggesting that better asthma control was associated with higher antioxidant intake (p < 0.05).
Plasma TAS levels in patients with severe asthma were significantly lower than in healthy individuals. Higher dietary antioxidant intake was positively associated with plasma TAS and may contribute to improved asthma control. These findings suggest that increasing dietary antioxidant intake could be beneficial in the management of severe asthma.
Not applicable.
本研究旨在评估重度哮喘患者的营养状况，并确定膳食抗氧化剂（AO）摄入量如何影响疾病预后和血浆总抗氧化状态（TAS）。
该研究纳入了44例重度哮喘患者和45名健康参与者。收集了每位参与者的人体测量数据、哮喘控制水平、经过验证的抗氧化剂食物消费频率问卷得分、3天食物记录以及人口统计学信息。对空腹过夜后采集的血样进行血浆TAS和总氧化状态（TOS）分析。
与对照组相比，哮喘组通过食物频率问卷（FFQ）和食物记录测得的平均抗氧化剂摄入量以及血浆TAS水平显著较低（p < 0.05）。在哮喘组中，哮喘病程与血浆TAS以及FFQ和食物记录中的抗氧化剂摄入量之间均呈负相关，表明哮喘病程越长，抗氧化状态越低（p < 0.05）。此外，病例组中哮喘控制水平与FFQ中的抗氧化剂摄入量之间呈正相关，提示哮喘控制越好，抗氧化剂摄入量越高（p < 0.05）。
重度哮喘患者的血浆TAS水平显著低于健康个体。较高的膳食抗氧化剂摄入量与血浆TAS呈正相关，可能有助于改善哮喘控制。这些发现表明增加膳食抗氧化剂摄入量可能对重度哮喘的管理有益。
不适用。
